PDB entry 5e8z

View 5e8z on RCSB PDB site
Description: tgf-beta receptor type 1 kinase domain (t204d) in complex with 3-amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide
Class: transferase/transferase inhibitor
Keywords: alk5, kinase domain, transferase-transferase inhibitor complex
Deposited on 2015-10-14, released 2016-05-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-05-11, with a file datestamp of 2016-05-06.
Experiment type: XRAY
Resolution: 1.51 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1, ALK5, SKR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36897 (3-End)
      • expression tag (0-2)
      • engineered mutation (7)
    Domains in SCOPe 2.07: d5e8za1, d5e8za2
  • Heterogens: 5L4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5e8zA (A:)
    ghmtiardivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrh
    enilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahl
    hmeivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtk
    rymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdp
    sveemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls
    qqegikm
    

    Sequence, based on observed residues (ATOM records): (download)
    >5e8zA (A:)
    ghmtiardivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrh
    enilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahl
    hmeivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtk
    rymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdp
    sveemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls
    qqe