PDB entry 5e8d

View 5e8d on RCSB PDB site
Description: Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal antibody 9E5
Class: immune system
Keywords: Antibody, Immunoglobulin, Monoclonal antibody, Epidermal growth factor, Cancer, IMMUNE SYSTEM
Deposited on 2015-10-14, released 2015-12-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-02-17, with a file datestamp of 2016-02-12.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proepiregulin
    Species: Homo sapiens [TaxId:9606]
    Gene: EREG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5e8da_
  • Chain 'H':
    Compound: anti-human epiregulin antibody 9E5 Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 5E8D (0-End)
  • Chain 'L':
    Compound: anti-human epiregulin antibody 9E5 Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 5E8D (0-End)
    Domains in SCOPe 2.07: d5e8dl1, d5e8dl2
  • Heterogens: CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5e8dA (A:)
gpamscipgessdnctalvqtednprvaqvsitkcssdmngyclhgqciylvdmsqnycr
cevgytgvrcehffl

    Sequence, based on observed residues (ATOM records): (download) 
    >5e8dA (A:)
itkcssdmngyclhgqciylvdmsqnycrcevgytgvrcehff

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5e8dL (L:)
diqmtqspsslsaslggkvtitckasqdinkyiawyqhkpgkgprllihytstlhpgips
rfsgsgsgrdysfsisnlepediatyyclqydnlrtfgggtkleikradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >5e8dL (L:)
diqmtqspsslsasgkvtitckasqdinkyiawyqhkpgkgprllihytstlhpgipsrf
sgsgsgrdysfsisnlepediatyyclqydnlrtfgggtkleikradaaptvsifppsse
qltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltltk
deyerhnsytceathktstspivksfnrne