PDB entry 5e0j

View 5e0j on RCSB PDB site
Description: 1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor
Class: protease/protease inhibitor
Keywords: protease, norovirus, norwalk virus, antiviral inhibitors, triazole macrocyclic inhibitor, cell permeable, PROTEASE-PROTEASE INHIBITOR complex
Deposited on 2015-09-28, released 2016-05-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.64 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Norovirus 3C-like protease
    Species: Norwalk virus [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.08: d5e0ja1, d5e0ja2
  • Heterogens: CL, 5LJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5e0jA (A:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >5e0jA (A:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa