PDB entry 5dwr

View 5dwr on RCSB PDB site
Description: Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies
Class: Transferase/Transferase Inhibitor
Keywords: Pim1, moloney murine leukemia, PIM447, kinase inhibitor, Transferase-Transferase Inhibitor complex
Deposited on 2015-09-22, released 2015-11-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-11-11, with a file datestamp of 2015-11-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d5dwra_
  • Heterogens: 5H7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5dwrA (A:)
mahhhhhhlevlfqgpllskinslahlraapcndlhatklapgkekeplesqyqvgpllg
sggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgfsgvir
lldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhchncgvlh
rdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsaav
wslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrptfeeiq
nhpwmqdvllpqetaeihlhslspgpsk

    Sequence, based on observed residues (ATOM records): (download) 
    >5dwrA (A:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlhs