PDB entry 5dt2

View 5dt2 on RCSB PDB site
Description: Crystal structure of Dot1L in complex with inhibitor CPD11 [N4-methyl-N2-(2-methyl-1-(2-phenoxyphenyl)-1H-indol-6-yl)pyrimidine-2,4-diamine]
Class: transferase
Keywords: Inhibitor, Complex, Methyltransferase, transferase
Deposited on 2015-09-17, released 2016-06-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-09-07, with a file datestamp of 2016-09-02.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5dt2a_
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5dt2b_
  • Heterogens: 5EV, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5dt2A (A:)
gpgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyv
lidydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsv
tdpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnc
khhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvif
vnnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelspl
kgsvswtgkpvsyylhtidrtilenyfsslknpg

    Sequence, based on observed residues (ATOM records): (download) 
    >5dt2A (A:)
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgntrpstgllrhilqqvynhsvtdpepfspevyg
etsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipakyaet
mdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhqlkerf
anmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkswtgkpvsyylhtidrt
ilenyfsslkn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5dt2B (B:)
gpgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyv
lidydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsv
tdpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnc
khhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvif
vnnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelspl
kgsvswtgkpvsyylhtidrtilenyfsslknpg

    Sequence, based on observed residues (ATOM records): (download) 
    >5dt2B (B:)
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgtlntrpstgllrhilqqvynhsvtdpekpfsp
evygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipak
yaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhql
kerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkvswtgkpvsyylh
tidrtilenyfsslk