PDB entry 5dh5
View 5dh5 on RCSB PDB site
Description: PDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase-hydrolase inhibitor complex
Deposited on
2015-08-29, released
2016-01-27
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-01-27, with a file datestamp of
2016-01-22.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Species: Homo sapiens [TaxId:9606]
Gene: PDE10A
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Species: Homo sapiens [TaxId:9606]
Gene: PDE10A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5dh5b1, d5dh5b2 - Heterogens: ZN, MG, 5AY, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5dh5B (B:)
gshmsictseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfe
leklcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchd
ldhrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvle
iirkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpv
tkltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqi
lpptepllkacrdnlsqwekvirgeetatwisspsvaqkaaased
Sequence, based on observed residues (ATOM records): (download)
>5dh5B (B:)
hmsictseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfele
klcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdld
hrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleii
rkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtk
ltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilp
ptepllkacrdnlsqwekvirge