PDB entry 5dg6

View 5dg6 on RCSB PDB site
Description: 2.35A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (21-mer) inhibitor
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: PROTEASE, NOROVIRUS, NORWALK VIRUS, ANTIVIRAL INHIBITORS, OXADIAZOLE INHIBITOR, CELL PERMEABLE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2015-08-27, released 2016-02-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-03-23, with a file datestamp of 2016-03-18.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like protease
    Species: Norwalk virus [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.06: d5dg6a1, d5dg6a2
  • Chain 'B':
    Compound: 3C-like protease
    Species: Norwalk virus [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.06: d5dg6b1, d5dg6b2
  • Heterogens: CL, V66, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5dg6A (A:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >5dg6A (A:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5dg6B (B:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >5dg6B (B:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmrvhgqsgmllg
tipgdcgapyvhkrgndwvvcgvhaaatktvvcavqa