PDB entry 5dfb

View 5dfb on RCSB PDB site
Description: Crystal structure of BRD2(BD2) mutant W370F in the free form
Class: transcription
Keywords: Transcription factors, BET bromodomains, protein mutation engineering, molecular probes, transcription
Deposited on 2015-08-26, released 2015-11-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-11-11, with a file datestamp of 2015-11-06.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440
      • engineered mutation (28)
    Domains in SCOPe 2.05: d5dfba_
  • Heterogens: NI, 2PE, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5dfbA (A:)
    smgklseqlkhcngilkellskkhaayafpfykpvdasalglhdyhdiikhpmdlstvkr
    kmenrdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd
    

    Sequence, based on observed residues (ATOM records): (download)
    >5dfbA (A:)
    seqlkhcngilkellskkhaayafpfykpvdasalglhdyhdiikhpmdlstvkrkmenr
    dyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmp