PDB entry 5d72

View 5d72 on RCSB PDB site
Description: Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Class: immune system
Keywords: GM-CSF, affinity maturation, phage display, cytokine, antibody, PROTEROS BIOSTRUCTURES GMBH, immune system
Deposited on 2015-08-13, released 2015-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-01-13, with a file datestamp of 2016-01-08.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04141 (Start-126)
      • expression tag (127-140)
    Domains in SCOPe 2.08: d5d72a1, d5d72a2
  • Chain 'B':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04141 (Start-126)
      • expression tag (127-140)
    Domains in SCOPe 2.08: d5d72b1, d5d72b2
  • Chain 'H':
    Compound: Immunglobulin G1 Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D72 (0-End)
  • Chain 'L':
    Compound: Immunglobulin G1 Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D72 (0-End)
    Domains in SCOPe 2.08: d5d72l1, d5d72l2
  • Chain 'M':
    Compound: Immunglobulin G1 Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D72 (0-End)
  • Chain 'N':
    Compound: Immunglobulin G1 Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D72 (0-End)
    Domains in SCOPe 2.08: d5d72n1, d5d72n2
  • Heterogens: PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5d72A (A:)
mwlqsllllgtvacsisaparspspstqpwehvnaiqearrllnlsrdtaaemnetvevi
semfdlqeptclqtrlelykqglrgsltklkgpltmmashykqhcpptpetscatqiitf
esfkenlkdfllvipfdcwep

    Sequence, based on observed residues (ATOM records): (download) 
    >5d72A (A:)
tqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglrgs
ltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcwep

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5d72B (B:)
mwlqsllllgtvacsisaparspspstqpwehvnaiqearrllnlsrdtaaemnetvevi
semfdlqeptclqtrlelykqglrgsltklkgpltmmashykqhcpptpetscatqiitf
esfkenlkdfllvipfdcwep

    Sequence, based on observed residues (ATOM records): (download) 
    >5d72B (B:)
pstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglr
gsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcwep

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5d72L (L:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvaptea

    Sequence, based on observed residues (ATOM records): (download) 
    >5d72L (L:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvap

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >5d72N (N:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvaptea

    Sequence, based on observed residues (ATOM records): (download) 
    >5d72N (N:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrerfsgsnsg
ntatltisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppsseelqa
nkatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltpeqwks
hrsyscqvthegstvektvap