PDB entry 5d70
View 5d70 on RCSB PDB site
Description: Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Class: immune system
Keywords: GM-CSF, affinity maturation, phage display, cytokine, antibody, PROTEROS BIOSTRUCTURES GMBH, immune system
Deposited on
2015-08-13, released
2015-10-14
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-01-13, with a file datestamp of
2016-01-08.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.3
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: granulocyte-macrophage colony-stimulating factor
Species: Homo sapiens [TaxId:9606]
Gene: CSF2, GMCSF
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5d70a1, d5d70a2 - Chain 'H':
Compound: Immunglobulin G1 Fab fragment, heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: Immunglobulin G1 Fab fragment, light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5d70l1, d5d70l2 - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5d70A (A:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe
Sequence, based on observed residues (ATOM records): (download)
>5d70A (A:)
pstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglr
gsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcw
- Chain 'H':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>5d70L (L:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvaptea
Sequence, based on observed residues (ATOM records): (download)
>5d70L (L:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlverfsgsnsgntatl
tisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppsseelqankatl
vclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltpeqwkshrsys
cqvthegstvektvapt