PDB entry 5d70

View 5d70 on RCSB PDB site
Description: Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Class: immune system
Keywords: GM-CSF, affinity maturation, phage display, cytokine, antibody, PROTEROS BIOSTRUCTURES GMBH, immune system
Deposited on 2015-08-13, released 2015-10-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-01-13, with a file datestamp of 2016-01-08.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5d70a1, d5d70a2
  • Chain 'H':
    Compound: Immunglobulin G1 Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D70 (0-End)
  • Chain 'L':
    Compound: Immunglobulin G1 Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D70 (0-End)
    Domains in SCOPe 2.07: d5d70l1, d5d70l2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5d70A (A:)
    aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
    lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
    cwepvqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >5d70A (A:)
    pstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglr
    gsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcw
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >5d70L (L:)
    dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
    gsnsgntatltisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppss
    eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
    eqwkshrsyscqvthegstvektvaptea
    

    Sequence, based on observed residues (ATOM records): (download)
    >5d70L (L:)
    dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlverfsgsnsgntatl
    tisgtqaedeadyycsswdstglvfgggtkltvlgqpkaapsvtlfppsseelqankatl
    vclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltpeqwkshrsys
    cqvthegstvektvapt