PDB entry 5d6d

View 5d6d on RCSB PDB site
Description: Crystal structure of GASDALIE IgG1 Fc in complex with FcgRIIIa
Class: immune system
Keywords: ADCC, Immune system, IgG
Deposited on 2015-08-12, released 2016-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.13 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (38)
      • engineered mutation (41)
      • engineered mutation (132)
      • engineered mutation (134)
    Domains in SCOPe 2.08: d5d6da1, d5d6da2
  • Chain 'B':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (38)
      • engineered mutation (41)
      • engineered mutation (132)
      • engineered mutation (134)
    Domains in SCOPe 2.08: d5d6db1, d5d6db2
  • Chain 'C':
    Compound: Low affinity immunoglobulin gamma Fc region receptor III-A
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGR3A, CD16A, FCG3, FCGR3, IGFR3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08637
      • engineered mutation (91)
      • engineered mutation (186)
    Domains in SCOPe 2.08: d5d6dc1, d5d6dc2
  • Heterogens: FUC, NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5d6dA (A:)
mefglswlflvailkgvqcevqlletstcppcpapellagpdvflfppkpkdtlmisrtp
evtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngk
eykckvsnkalplpeektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdi
avewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt
qkslslspg

    Sequence, based on observed residues (ATOM records): (download) 
    >5d6dA (A:)
agpdvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalplpeektiskakgqprepqvytlppsr
deltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdks
rwqqgnvfscsvmhealhnhytqkslsls

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5d6dB (B:)
mefglswlflvailkgvqcevqlletstcppcpapellagpdvflfppkpkdtlmisrtp
evtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngk
eykckvsnkalplpeektiskakgqprepqvytlppsrdeltknqvsltclvkgfypsdi
avewesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt
qkslslspg

    Sequence, based on observed residues (ATOM records): (download) 
    >5d6dB (B:)
agpdvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalplpeektiskakgqprepqvytlppsr
deltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdks
rwqqgnvfscsvmhealhnhytqkslsl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5d6dC (C:)
mwqlllptallllvsagmrtedlpkavvflepqwyrvlekdsvtlkcqgayspedqstqw
fhneslissqassyfidaatvddsgeyrcqtqlstlsdpvqlevhigwlllqaprwvfke
edpihlrchswkntalhkvtylqngkgrkyfhhnsdfyipkatlkdsgsyfcrglfgskn
vssetvqititqglavstissffppsrggggsgggghvlndifeaqkiewhetghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5d6dC (C:)
avvflepqwyrvlekdsvtlkcqgatqwfhneslissqassyfidaatvddsgeyrcqtq
lsdpvqlevhigwlllqaprwvfkeedpihlrchswkntalhkvtylqngkgrkyfhhns
dfyipkatlkdsgsyfcrglfgsknvssetvqititq