PDB entry 5d3s

View 5d3s on RCSB PDB site
Description: First bromodomain of BRD4 bound to inhibitor XD44
Class: transcription
Keywords: Gene regulation, Bromodomain, Inhibitor, transcription
Deposited on 2015-08-06, released 2016-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5d3sa1, d5d3sa2
  • Heterogens: 579, DMS, BU3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5d3sA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elptee

    Sequence, based on observed residues (ATOM records): (download) 
    >5d3sA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpte