PDB entry 5d2b
View 5d2b on RCSB PDB site
Description: Crystal structure of a mutated catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470
Class: hydrolase
Keywords: Metzincin, Matrix Metallo Elastase, MMP12, human, RXP470, Macrophage, Hydrolase, Hydroxamate based inhibitor
Deposited on
2015-08-05, released
2016-08-17
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-12-20, with a file datestamp of
2017-12-15.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.65
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- initiating methionine (0)
- engineered mutation (66)
Domains in SCOPe 2.07: d5d2ba1, d5d2ba2 - Heterogens: ZN, CA, 56O, HOH