PDB entry 5d12

View 5d12 on RCSB PDB site
Description: Kinase domain of cSrc in complex with RL40
Class: transferase
Keywords: kinase inhibitor, drug resistance, transferase
Deposited on 2015-08-03, released 2015-09-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-09-23, with a file datestamp of 2015-09-18.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.06: d5d12a_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.06: d5d12b_
  • Heterogens: G97

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5d12A (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >5d12A (A:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlspeaflqeaqvmkklrhek
lvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermn
yvhrdlraanilvgenlvckvadfglarlifpikwtapeaalygrftiksdvwsfgillt
elttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylq
afledyftstepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5d12B (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >5d12B (B:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktleaflqeaqvmkklrheklvq
lyavvseepiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvh
rdlraanilvgenlvckvadfglfpikwtapeaalygrftiksdvwsfgilltelttkgr
vpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyf
tstepqyqpgenl