SCOPe 2.07: Structural Classification of Proteins

PDB entry 5ctc

View 5ctc on RCSB PDB site
Description: Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate
Class: transferase/transferase inhibitor
Keywords: ACC, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2015-07-23, released 2015-10-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-11-11, with a file datestamp of 2015-11-06.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: acetyl-coa carboxylase
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: ACC1, ABP2, FAS3, MTR7, YNR016C, N3175
Database cross-references and differences (RAF-indexed):
- Uniprot Q00955
  - engineered mutation (287)
  - engineered mutation (289)
  - engineered mutation (292)
  - engineered mutation (446-447)
  - engineered mutation (452)
  - engineered mutation (555)
  - engineered mutation (557)
  - engineered mutation (559)
Domains in SCOPe 2.07: d5ctca1, d5ctca2
Chain 'B':
Compound: acetyl-coa carboxylase
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: ACC1, ABP2, FAS3, MTR7, YNR016C, N3175
Database cross-references and differences (RAF-indexed):
- Uniprot Q00955
  - engineered mutation (287)
  - engineered mutation (289)
  - engineered mutation (292)
  - engineered mutation (446-447)
  - engineered mutation (452)
  - engineered mutation (555)
  - engineered mutation (557)
  - engineered mutation (559)
Domains in SCOPe 2.07: d5ctcb1, d5ctcb2
Chain 'C':
Compound: acetyl-coa carboxylase
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: ACC1, ABP2, FAS3, MTR7, YNR016C, N3175
Database cross-references and differences (RAF-indexed):
- Uniprot Q00955
  - engineered mutation (287)
  - engineered mutation (289)
  - engineered mutation (292)
  - engineered mutation (446-447)
  - engineered mutation (452)
  - engineered mutation (555)
  - engineered mutation (557)
  - engineered mutation (559)
Domains in SCOPe 2.07: d5ctcc1, d5ctcc2
Heterogens: 57K, SO4, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>5ctcA (A:)
masgsmhlrpiatpypvkewlqpkrykahlmgttyvydfpelfrqasssqwknfsadvkl
tddffisneliedengelteverepganaigmvafkitvktpeyprgrqfvvvanditfk
igsfgpqedeffnkvteyarkrgipriylaansgarigmaeeivplfqvawndaanpdkg
fqylyltsegmetlkkfdkensvltertvingeerfviktiigsedglgveclrgsglia
gatsrayhdiftitlvtcrsvgigaylvrlgqraiqvegqpiiltgasalnkvlgrevyt
snlqlggtqimynngvshltavddlagvekivewmsyvpakrnmpvpiletkdtwdrpvd
ftptndetydvrwmiegretesgfeyglfdkgsffetlsgwakgvvvgrarlggiplgvi
gvetrtvenlipadpanpnsaetliqqagqvwfpnsafktaqaindfnngeqlpmmilan
wrgfsggqrdmfnevlkygsfivdalvdykqpiiiyipptgelrggswvvvdptinadqm
emyadvnaragvlepegtveikfrreklldtmnrlddkyrelrsqlsnkslapevhqqis
kqladrerellpiygqislqfadlhdrssrmvakgviskelewtearrfffwrlrrrlne
eylikrlshqvgeasrlekiarirswypasvdheddrqvatwieenyktlddklkglkle
sfaqdlakkirsdhdnaidglsevikmlstddkekllktlklehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>5ctcA (A:)
lrpiatpypvkewlqpkrykahlmgttyvydfpelfrqasssqwknfsadvkltddffis
neliedengelteverepganaigmvafkitvktpeyprgrqfvvvanditfkigsfgpq
edeffnkvteyarkrgipriylaansgarigmaeeivplfqvawndaanpdkgfqylylt
segmetlkkfdkensvltertvingeerfviktiigsedglgveclrgsgliagatsray
hdiftitlvtcrsvgigaylvrlgqraiqvegqpiiltgasalnkvlgrevytsnlqlgg
tqimynngvshltavddlagvekivewmsyvpakrnmpvpiletkdtwdrpvdftptnde
tydvrwmiegretesgfeyglfdkgsffetlsgwakgvvvgrarlggiplgvigvetrtv
enlipadpanpnsaetliqqagqvwfpnsafktaqaindfnngeqlpmmilanwrgfsgg
qrdmfnevlkygsfivdalvdykqpiiiyipptgelrggswvvvdptinadqmemyadvn
aragvlepegtveikfrreklldtmnrlddkyrkqladrerellpiygqislqfadlhdr
ssrmvakgviskelewtearrfffwrlrrrlneeylikrlsheasrlekiarirswypas
vdheddrqvatwieenyktlddklkglkles

Chain 'B':
Sequence, based on SEQRES records: (download)

>5ctcB (B:)
masgsmhlrpiatpypvkewlqpkrykahlmgttyvydfpelfrqasssqwknfsadvkl
tddffisneliedengelteverepganaigmvafkitvktpeyprgrqfvvvanditfk
igsfgpqedeffnkvteyarkrgipriylaansgarigmaeeivplfqvawndaanpdkg
fqylyltsegmetlkkfdkensvltertvingeerfviktiigsedglgveclrgsglia
gatsrayhdiftitlvtcrsvgigaylvrlgqraiqvegqpiiltgasalnkvlgrevyt
snlqlggtqimynngvshltavddlagvekivewmsyvpakrnmpvpiletkdtwdrpvd
ftptndetydvrwmiegretesgfeyglfdkgsffetlsgwakgvvvgrarlggiplgvi
gvetrtvenlipadpanpnsaetliqqagqvwfpnsafktaqaindfnngeqlpmmilan
wrgfsggqrdmfnevlkygsfivdalvdykqpiiiyipptgelrggswvvvdptinadqm
emyadvnaragvlepegtveikfrreklldtmnrlddkyrelrsqlsnkslapevhqqis
kqladrerellpiygqislqfadlhdrssrmvakgviskelewtearrfffwrlrrrlne
eylikrlshqvgeasrlekiarirswypasvdheddrqvatwieenyktlddklkglkle
sfaqdlakkirsdhdnaidglsevikmlstddkekllktlklehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>5ctcB (B:)
rpiatpypvkewlqpkrykahlmgttyvydfpelfrqasssqwknfsadvkltddffisn
eliedengelteverepganaigmvafkitvktpeyprgrqfvvvanditfkigsfgpqe
deffnkvteyarkrgipriylaansgarigmaeeivplfqvawndaanpdkgfqylylts
egmetlkkfdkensvltertvingeerfviktiigsedglgveclrgsgliagatsrayh
diftitlvtcrsvgigaylvrlgqraiqvegqpiiltgasalnkvlgrevytsnlqlggt
qimynngvshltavddlagvekivewmsyvpakrnmpvpiletkdtwdrpvdftptndet
ydvrwmiegretesgfeyglfdkgsffetlsgwakgvvvgrarlggiplgvigvetrtve
nlipadpanpnsaetliqqagqvwfpnsafktaqaindfnngeqlpmmilanwrgfsggq
rdmfnevlkygsfivdalvdykqpiiiyipptgelrggswvvvdptinadqmemyadvna
ragvlepegtveikfrreklldtmnrlddkyrelladrerellpiygqislqfadlhdrs
srmvakgviskelewtearrfffwrlrrrlneeylikrlshqvasrlekiarirswypas
vdheddrqvatwieenyktlddklkgl

Chain 'C':
Sequence, based on SEQRES records: (download)

>5ctcC (C:)
masgsmhlrpiatpypvkewlqpkrykahlmgttyvydfpelfrqasssqwknfsadvkl
tddffisneliedengelteverepganaigmvafkitvktpeyprgrqfvvvanditfk
igsfgpqedeffnkvteyarkrgipriylaansgarigmaeeivplfqvawndaanpdkg
fqylyltsegmetlkkfdkensvltertvingeerfviktiigsedglgveclrgsglia
gatsrayhdiftitlvtcrsvgigaylvrlgqraiqvegqpiiltgasalnkvlgrevyt
snlqlggtqimynngvshltavddlagvekivewmsyvpakrnmpvpiletkdtwdrpvd
ftptndetydvrwmiegretesgfeyglfdkgsffetlsgwakgvvvgrarlggiplgvi
gvetrtvenlipadpanpnsaetliqqagqvwfpnsafktaqaindfnngeqlpmmilan
wrgfsggqrdmfnevlkygsfivdalvdykqpiiiyipptgelrggswvvvdptinadqm
emyadvnaragvlepegtveikfrreklldtmnrlddkyrelrsqlsnkslapevhqqis
kqladrerellpiygqislqfadlhdrssrmvakgviskelewtearrfffwrlrrrlne
eylikrlshqvgeasrlekiarirswypasvdheddrqvatwieenyktlddklkglkle
sfaqdlakkirsdhdnaidglsevikmlstddkekllktlklehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>5ctcC (C:)
lqpkrykahlmgttyvydfpelfrqasssqwknfsadvkltddffisneliedengelte
verepganaigmvafkitvktpeyprgrqfvvvanditfkigsfgpqedeffnkvteyar
krgipriylaansgarigmaeeivplfqvawndaanpdkgfqylyltsegmetlkkfdke
nsvltertvingeerfviktiigsedglgveclrgsgliagatsrayhdiftitlvtcrs
vgigaylvrlgqraiqvegqpiiltgasalnkvlgrevytsnlqlggtqimynngvshlt
avddlagvekivewmsyvpakrnmpvpiletkdtwdrpvdftptndetydvrwmiegret
esgfeyglfdkgsffetlsgwakgvvvgrarlggiplgvigvetrtvenlipadpanpns
aetliqqagqvwfpnsafktaqaindfnngeqlpmmilanwrgfsggqrdmfnevlkygs
fivdalvdykqpiiiyipptgelrggswvvvdptinadqmemyadvnaragvlepegtve
ikfrreklldtmnrlddkyrelrsqladrerellpiygqislqfadlhdrssrmvakgvi
skelewtearrfffwrlrrrlneeylikrlshqeasrlekiarirswypasvdheddrqv
atwieenyktlddklkglkle