SCOPe 2.08: Structural Classification of Proteins

PDB entry 5cox

View 5cox on RCSB PDB site
Description: uninhibited mouse cyclooxygenase-2 (prostaglandin synthase-2)
Class: oxidoreductase
Keywords: peroxidase, dioxygenase, cyclooxygenase, nonsteroidal antiinflammatory drugs, inflammation, arthritis, prostaglandin, prostaglandin synthase, oxidoreductase
Deposited on 1996-12-18, released 1997-12-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: cyclooxygenase-2
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Uniprot Q05769 (0-End)
  - conflict (278)
  - conflict (301)
Domains in SCOPe 2.08: d5coxa1, d5coxa2
Chain 'B':
Compound: cyclooxygenase-2
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Uniprot Q05769 (0-End)
  - conflict (278)
  - conflict (301)
Domains in SCOPe 2.08: d5coxb1, d5coxb2
Chain 'C':
Compound: cyclooxygenase-2
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Uniprot Q05769 (0-End)
  - conflict (278)
  - conflict (301)
Domains in SCOPe 2.08: d5coxc1, d5coxc2
Chain 'D':
Compound: cyclooxygenase-2
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Uniprot Q05769 (0-End)
  - conflict (278)
  - conflict (301)
Domains in SCOPe 2.08: d5coxd1, d5coxd2
Heterogens: NAG, HEM

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>5coxA (A:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvqdpqptktatinasashsrlddinptvlikrrstel

Sequence, based on observed residues (ATOM records): (download)

>5coxA (A:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvq

Chain 'B':
Sequence, based on SEQRES records: (download)

>5coxB (B:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvqdpqptktatinasashsrlddinptvlikrrstel

Sequence, based on observed residues (ATOM records): (download)

>5coxB (B:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvq

Chain 'C':
Sequence, based on SEQRES records: (download)

>5coxC (C:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvqdpqptktatinasashsrlddinptvlikrrstel

Sequence, based on observed residues (ATOM records): (download)

>5coxC (C:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvq

Chain 'D':
Sequence, based on SEQRES records: (download)

>5coxD (D:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvqdpqptktatinasashsrlddinptvlikrrstel

Sequence, based on observed residues (ATOM records): (download)

>5coxD (D:)
anpccsnpcqnrgecmstgfdqykcdctrtgfygencttpefltriklllkptpntvhyi
lthfkgvwnivnnipflrslimkyvltsrsylidspptynvhygyksweafsnlsyytra
lppvaddcptpmgvkgnkelpdskevlekvllrrefipdpqgsnmmfaffaqhfthqffk
tdhkrgpgftrglghgvdlnhiygetldrqhklrlfkdgklkyqviggevypptvkdtqv
emiypphipenlqfavgqevfglvpglmmyatiwlrehqrvcdilkqehpewgdeqlfqt
skliligetikiviedyvqhlsgyhfklkfdpellfnqqfqyqnriasefntlyhwhpll
pdtfniedqeysfkqflynnsillehgltqfvesftrqiagrvaggrnvpiavqavakas
idqsremkyqslneyrkrfslkpytsfeeltgekemaaelkalysdidvmelypallvek
prpdaifgetmvelgapfslkglmgnpicspqywkpstfggevgfkiintasiqslicnn
vkgcpftsfnvq