PDB entry 5cns

View 5cns on RCSB PDB site
Description: Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution
Class: oxidoreductase
Keywords: allostery, substrate specificity, ribonucleotide reductase, nucleotide metabolism, OXIDOREDUCTASE
Deposited on 2015-07-18, released 2016-01-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.98 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ribonucleoside-diphosphate reductase 1 subunit alpha
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdA, dnaF, b2234, JW2228
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cnsa1, d5cnsa2
  • Chain 'B':
    Compound: ribonucleoside-diphosphate reductase 1 subunit alpha
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdA, dnaF, b2234, JW2228
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cnsb1, d5cnsb2
  • Chain 'C':
    Compound: ribonucleoside-diphosphate reductase 1 subunit alpha
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdA, dnaF, b2234, JW2228
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cnsc1, d5cnsc2
  • Chain 'D':
    Compound: ribonucleoside-diphosphate reductase 1 subunit alpha
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdA, dnaF, b2234, JW2228
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5cnsd1, d5cnsd2
  • Chain 'E':
    Compound: ribonucleoside-diphosphate reductase 1 subunit beta
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdB, ftsB, b2235, JW2229
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: ribonucleoside-diphosphate reductase 1 subunit beta
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdB, ftsB, b2235, JW2229
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: ribonucleoside-diphosphate reductase 1 subunit beta
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdB, ftsB, b2235, JW2229
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: ribonucleoside-diphosphate reductase 1 subunit beta
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: nrdB, ftsB, b2235, JW2229
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CDP, DAT, MG, DTP, FEO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5cnsA (A:)
mnqnllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihe
tiikaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhll
edyteeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaacl
fsnypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinat
ssaivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrgg
aatlfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsd
vpglydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhc
nthspfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldelee
lailavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlt
hktfeaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwe
alresikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdye
hlhdayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdllt
aykfgvktlyyqntrdgaedaqddlvpsiqddgcesgacki

    Sequence, based on observed residues (ATOM records): (download) 
    >5cnsA (A:)
llvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihetiik
aaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhlledyt
eeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaaclfsny
pretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinatssai
vkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrggaatl
fypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsdvpgl
ydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhcnths
pfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldeleelail
avraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlthktf
eaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwealre
sikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdyehlhd
ayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdlltaykf
gvktlyyqntrd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5cnsB (B:)
mnqnllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihe
tiikaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhll
edyteeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaacl
fsnypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinat
ssaivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrgg
aatlfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsd
vpglydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhc
nthspfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldelee
lailavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlt
hktfeaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwe
alresikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdye
hlhdayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdllt
aykfgvktlyyqntrdgaedaqddlvpsiqddgcesgacki

    Sequence, based on observed residues (ATOM records): (download) 
    >5cnsB (B:)
nllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihetii
kaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhlledy
teeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaaclfsn
ypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinatssa
ivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrggaat
lfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsdvpg
lydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhcnth
spfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldeleelai
lavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlthkt
feaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwealr
esikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdyehlh
dayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdlltayk
fgvktlyyqntrdg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5cnsC (C:)
mnqnllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihe
tiikaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhll
edyteeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaacl
fsnypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinat
ssaivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrgg
aatlfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsd
vpglydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhc
nthspfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldelee
lailavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlt
hktfeaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwe
alresikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdye
hlhdayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdllt
aykfgvktlyyqntrdgaedaqddlvpsiqddgcesgacki

    Sequence, based on observed residues (ATOM records): (download) 
    >5cnsC (C:)
llvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihetiik
aaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhlledyt
eeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaaclfsny
pretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinatssai
vkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrggaatl
fypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsdvpgl
ydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhcnths
pfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldeleelail
avraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlthktf
eaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwealre
sikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdyehlhd
ayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdlltaykf
gvktlyyqntrd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5cnsD (D:)
mnqnllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihe
tiikaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhll
edyteeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaacl
fsnypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinat
ssaivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrgg
aatlfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsd
vpglydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhc
nthspfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldelee
lailavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlt
hktfeaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwe
alresikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdye
hlhdayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdllt
aykfgvktlyyqntrdgaedaqddlvpsiqddgcesgacki

    Sequence, based on observed residues (ATOM records): (download) 
    >5cnsD (D:)
nllvtkrdgsterinldkihrvldwaaeglhnvsisqvelrshiqfydgiktsdihetii
kaaadlisrdapdyqylaarlaifhlrkkaygqfeppalydhvvkmvemgkydnhlledy
teeefkqmdtfidhdrdmtfsyaavkqlegkylvqnrvtgeiyesaqflyilvaaclfsn
ypretrlqyvkrfydavstfkislptpimsgvrtptrqfsscvliecgdsldsinatssa
ivkyvsqragiginagriralgspirggeafhtgcipfykhfqtavkscsqggvrggaat
lfypmwhlevesllvlknnrgvegnrvrhmdygvqinklmytrllkgeditlfspsdvpg
lydaffadqeeferlytkyekddsirkqrvkavelfslmmqerastgriyiqnvdhcnth
spfdpaiapvrqsnlcleialptkplndvndengeialctlsafnlgainnldeleelai
lavraldalldyqdypipaakrgamgrrtlgigvinfayylakhgkrysdgsannlthkt
feaiqyyllkasnelakeqgacpwfnettyakgilpidtykkdldtianeplhydwealr
esikthglrnstlsalmpsetssqisnatngiepprgyvsikaskdgilrqvvpdyehlh
dayellwempgndgylqlvgimqkfidqsisantnydpsrfpsgkvpmqqllkdlltayk
fgvktlyyqntrdg

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.