PDB entry 5ccz

View 5ccz on RCSB PDB site
Description: Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 3-(4-fluorophenyl)-4-methyl-1H-pyrazol-5-amine
Class: transferase
Keywords: Fragment, Complex, Acetyltransferase, TRANSFERASE
Deposited on 2015-07-02, released 2016-08-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malate synthase g
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: glcB, Rv1837c, MTCY1A11.06
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WK17
      • engineered mutation (618)
    Domains in SCOPe 2.07: d5ccza_
  • Heterogens: 50C, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5cczA (A:)
    mtdrvsvgnlriarvlydfvnnealpgtdidpdsfwagvdkvvadltpqnqallnardel
    qaqidkwhrrrviepidmdayrqflteigyllpepddftittsgvdaeitttagpqlvvp
    vlnarfalnaanarwgslydalygtdvipetdgaekgptynkvrgdkviayarkflddsv
    plssgsfgdatgftvqdgqlvvalpdkstglanpgqfagytgaaesptsvllinhglhie
    ilidpesqvgttdragvkdvilesaittimdfedsvaavdaadkvlgyrnwlglnkgdla
    aavdkdgtaflrvlnrdrnytapgggqftlpgrslmfvrnvghlmtndaivdtdgsevfe
    gimdalftgliaihglkasdvngplinsrtgsiyivkpkmhgpaevaftcelfsrvedvl
    glpqntmkigimdeerrttvnlkacikaaadrvvfintgfldrtgdeihtsmeagpmvrk
    gtmksqpwilayedhnvdaglaagfsgraqvgkgmwtmtelmadmvetkiaqpragasta
    wvpsptaatlhalhyhqvdvaavqqglagkrratieqlltiplakelawapdeireevdn
    ncqsilgyvvrwvdqgvgaskvpdihdvalmedratlrissqllanwlrhgvitsadvra
    slermaplvdrqnagdvayrpmapnfddsiaflaaqelilsgaqqpngytepilhrrrre
    fkaraaekpapsdragddaar
    

    Sequence, based on observed residues (ATOM records): (download)
    >5cczA (A:)
    tdrvsvgnlriarvlydfvnnealpgtdidpdsfwagvdkvvadltpqnqallnardelq
    aqidkwhrrrpidmdayrqflteigyllpepddftittsgvdaeitttagpqlvvpvlna
    rfalnaanarwgslydalygtdvipetdgaekgptynkvrgdkviayarkflddsvplss
    gsfgdatgftvqdgqlvvalpdkstglanpgqfagytgaaesptsvllinhglhieilid
    pesqvgttdragvkdvilesaittimdfedsvaavdaadkvlgyrnwlglnkgdlaarvl
    nrdrnytapgggqftlpgrslmfvrnvghlmtndaivdtdgsevfegimdalftgliaih
    glkasdvngplinsrtgsiyivkpkmhgpaevaftcelfsrvedvlglpqntmkigimde
    errttvnlkacikaaadrvvfintgfldrtgdeihtsmeagpmvrkgtmksqpwilayed
    hnvdaglaagfsgraqvgkgmwtmtelmadmvetkiaqpragastawvpsptaatlhalh
    yhqvdvaavqqglagkrratieqlltiplakelawapdeireevdnncqsilgyvvrwvd
    qgvgaskvpdihdvalmedratlrissqllanwlrhgvitsadvraslermaplvdrqna
    gdvayrpmapnfddsiaflaaqelilsgaqqpngytepilhrrrrefkaraae