PDB entry 5c7x

View 5c7x on RCSB PDB site
Description: Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Class: immune system
Keywords: GM-CSF, affinity maturation, phage display, cytokine, antibody, PROTEROS BIOSTRUCTURES GMBH, immune system
Deposited on 2015-06-25, released 2015-10-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-01-13, with a file datestamp of 2016-01-08.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5c7xa1, d5c7xa2
  • Chain 'B':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5c7xb1, d5c7xb2
  • Chain 'H':
    Compound: Immunglobulin G1 Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5C7X (0-End)
  • Chain 'L':
    Compound: Immunglobulin G1 Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5C7X (0-End)
    Domains in SCOPe 2.06: d5c7xl1, d5c7xl2
  • Chain 'M':
    Compound: Immunglobulin G1 Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5C7X (0-End)
  • Chain 'N':
    Compound: Immunglobulin G1 Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5C7X (0-End)
    Domains in SCOPe 2.06: d5c7xn1, d5c7xn2
  • Heterogens: PGE, PEG, PG6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5c7xA (A:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >5c7xA (A:)
stqpwehvnaiqearrllnlsrtaaemnetvevisemfdlqeptclqtrlelykqglrgs
ltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcwep

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5c7xB (B:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >5c7xB (B:)
stqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglrg
sltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfdcwep

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5c7xL (L:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsawgdkgmvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvaptea

    Sequence, based on observed residues (ATOM records): (download) 
    >5c7xL (L:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsawgdkgmvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvap

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >5c7xN (N:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrpsgiperfs
gsnsgntatltisgtqaedeadyycsawgdkgmvfgggtkltvlgqpkaapsvtlfppss
eelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltp
eqwkshrsyscqvthegstvektvaptea

    Sequence, based on observed residues (ATOM records): (download) 
    >5c7xN (N:)
dieltqppsvsvapgqtariscsgdsigkkyaywyqqkpgqapvlviykkrerfsgsnsg
ntatltisgtqaedeadyycsawgdkgmvfgggtkltvlgqpkaapsvtlfppsseelqa
nkatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsltpeqwks
hrsyscqvthegstvektvap