PDB entry 5bx0

View 5bx0 on RCSB PDB site
Description: An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery
Class: transferase
Keywords: fragment screening, microscale thermophoresis, transferase
Deposited on 2015-06-08, released 2015-12-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-12-23, with a file datestamp of 2015-12-18.
Experiment type: XRAY
Resolution: 2.93 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d5bx0a_
  • Heterogens: 4W5

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5bx0A (A:)
gleeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvma
rklihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvl
kkagripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgql
idsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmf
gcqvegdaaetpprprtpgrplnkkgmdsrppmaifelldyivnepppklpsgvfslefq
dfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq

    Sequence, based on observed residues (ATOM records): (download) 
    >5bx0A (A:)
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcp
maifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdae
evdfagwlcstigln