PDB entry 5bw2

View 5bw2 on RCSB PDB site
Description: X-ray crystal structure of Aplysia californica acetylcholine binding protein (Ac-AChBP) Y55W in complex with 2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane; 2-(3-pyridyl)quinuclidine; 2-PQ (TI-4699)
Class: acetylcholine binding protein
Keywords: AChBP, nicotine, acetylcholine, ACETYLCHOLINE BINDING PROTEIN
Deposited on 2015-06-05, released 2015-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-06-24, with a file datestamp of 2015-06-19.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (6-8)
      • engineered mutation (63)
    Domains in SCOPe 2.08: d5bw2a1, d5bw2a2
  • Chain 'B':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • engineered mutation (63)
    Domains in SCOPe 2.08: d5bw2b_
  • Chain 'C':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (6-8)
      • engineered mutation (63)
    Domains in SCOPe 2.08: d5bw2c1, d5bw2c2
  • Chain 'D':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • engineered mutation (63)
    Domains in SCOPe 2.08: d5bw2d_
  • Chain 'E':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (6-8)
      • engineered mutation (63)
    Domains in SCOPe 2.08: d5bw2e1, d5bw2e2
  • Heterogens: 4VU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5bw2A (A:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >5bw2A (A:)
dklhsqanlmrlksdlfnrsmypgptkddpltvtlgftlqdivkadsstnevdlvyweqq
rwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfi
paqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeils
atqtrqvqhysccpepyidvnlvvkfrerra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5bw2B (B:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >5bw2B (B:)
sqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwklnslm
wdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqrlsfm
cdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqtrqvq
hysccpepyidvnlvvkfrerra

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5bw2C (C:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >5bw2C (C:)
dklhsqanlmrlksdlfnrypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrw
klnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipa
qrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsat
qtrqvqhysccpepyidvnlvvkfrerra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5bw2D (D:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >5bw2D (D:)
sqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwklnslm
wdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqrlsfm
cdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqtrqvq
hysccpepyidvnlvvkfrerra

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5bw2E (E:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyweqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >5bw2E (E:)
dklhsqanlmrlksdlfypgptkddpltvtlgftlqdivkadsstnevdlvyweqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrerra