PDB entry 5bvo

View 5bvo on RCSB PDB site
Description: Fragment-based discovery of potent and selective DDR1/2 inhibitors
Class: transferase
Keywords: DDR1, fragments, transferase
Deposited on 2015-06-05, released 2015-08-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-08-05, with a file datestamp of 2015-07-31.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: epithelial discoidin domain-containing receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5bvoa1, d5bvoa2
  • Heterogens: IOD, 4VE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5bvoA (A:)
gamgsavgdgpprvdfprsrlrfkeklgegqfgevhlcevdspqdlvsldfplnvrkghp
llvavkilrpdatknarndflkevkimsrlkdpniirllgvcvqddplcmitdymengdl
nqflsahqledkaaegapgdgqaaqgptisypmllhvaaqiasgmrylatlnfvhrdlat
rnclvgenftikiadfgmsrnlyagdyyrvqgravlpirwmawecilmgkfttasdvwaf
gvtlwevlmlcraqpfgqltdeqvienageffrdqgrqvylsrppacpqglyelmlrcws
reseqrppfsqlhrflaedalntv

    Sequence, based on observed residues (ATOM records): (download) 
    >5bvoA (A:)
dfprsrlrfkeklgefgevhlcevdshpllvavkilrpdatknarndflkevkimsrlkd
pniirllgvcvqddplcmitdymengdlnqflsahqledkptisypmllhvaaqiasgmr
ylatlnfvhrdlatrnclvgenftikiadfgmsrnlyagdyyrvqgravlpirwmaweci
lmgkfttasdvwafgvtlwevlmlcraqpfgqltdeqvienageffrdqgrqvylsrppa
cpqglyelmlrcwsreseqrppfsqlhrflaedaln