PDB entry 5bvj

View 5bvj on RCSB PDB site
Description: The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta
Class: immune system
Keywords: immunoglobulin, Fab, immune system
Deposited on 2015-06-05, released 2015-09-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: canakinumab Fab light-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-213)
    Domains in SCOPe 2.08: d5bvja1, d5bvja2
  • Chain 'B':
    Compound: canakinumab Fab heavy-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-End)
    Domains in SCOPe 2.08: d5bvjb_
  • Chain 'C':
    Compound: canakinumab Fab light-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-213)
    Domains in SCOPe 2.08: d5bvjc1, d5bvjc2
  • Chain 'D':
    Compound: canakinumab Fab heavy-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-End)
    Domains in SCOPe 2.08: d5bvjd_
  • Chain 'E':
    Compound: canakinumab Fab light-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-213)
    Domains in SCOPe 2.08: d5bvje1, d5bvje2
  • Chain 'F':
    Compound: canakinumab Fab heavy-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-End)
    Domains in SCOPe 2.08: d5bvjf_
  • Chain 'G':
    Compound: canakinumab Fab light-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-213)
    Domains in SCOPe 2.08: d5bvjg1, d5bvjg2
  • Chain 'H':
    Compound: canakinumab Fab heavy-chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5BVJ (0-End)
    Domains in SCOPe 2.08: d5bvjh_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5bvjA (A:)
eivltqspdfqsvtpkekvtitcrasqsigsslhwyqqkpdqspkllikyasqsfsgvps
rfsgsgsgtdftltinsleaedaaayychqssslpftfgpgtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5bvjB (B:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >5bvjB (B:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkt

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5bvjC (C:)
eivltqspdfqsvtpkekvtitcrasqsigsslhwyqqkpdqspkllikyasqsfsgvps
rfsgsgsgtdftltinsleaedaaayychqssslpftfgpgtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5bvjD (D:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >5bvjD (D:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscd

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5bvjE (E:)
eivltqspdfqsvtpkekvtitcrasqsigsslhwyqqkpdqspkllikyasqsfsgvps
rfsgsgsgtdftltinsleaedaaayychqssslpftfgpgtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5bvjF (F:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >5bvjF (F:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv
tvpssslgtqtyicnvnhkpsntkvdkrvepk

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5bvjG (G:)
eivltqspdfqsvtpkekvtitcrasqsigsslhwyqqkpdqspkllikyasqsfsgvps
rfsgsgsgtdftltinsleaedaaayychqssslpftfgpgtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5bvjH (H:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkth

    Sequence, based on observed residues (ATOM records): (download) 
    >5bvjH (H:)
evqlvesgggvvqpgrslrlscaasgftfsvygmnwvrqapgkglewvaiiwydgdnqyy
adsvkgrftisrdnskntlylqmnglraedtavyycardlrtgpfdywgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvep