PDB entry 5bnv

View 5bnv on RCSB PDB site
Description: Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
Class: chaperone/DNA binding protein
Keywords: DNA replication, MCM2 helicase, histone chaperone, H3-H4 tetramer, CHAPERONE-DNA BINDING PROTEIN complex
Deposited on 2015-05-26, released 2015-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Histone H3.3
  Species: Homo sapiens [TaxId:9606]
  Gene: H3F3A, H3.3A, H3F3, PP781, H3F3B, H3.3B
  Database cross-references and differences (RAF-indexed):
  • Uniprot P84243
  Domains in SCOPe 2.08: d5bnva_
• Chain 'B':
  Compound: histone h4
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62805
  Domains in SCOPe 2.08: d5bnvb_
• Chain 'C':
  Compound: DNA replication licensing factor mcm2
  Species: Homo sapiens [TaxId:9606]
  Gene: MCM2, BM28, CCNL1, CDCL1, KIAA0030
  Database cross-references and differences (RAF-indexed):
  • Uniprot P49736
• Chain 'D':
  Compound: Histone H3.3
  Species: Homo sapiens [TaxId:9606]
  Gene: H3F3A, H3.3A, H3F3, PP781, H3F3B, H3.3B
  Database cross-references and differences (RAF-indexed):
  • Uniprot P84243 (Start-78)
  Domains in SCOPe 2.08: d5bnvd_
• Chain 'E':
  Compound: histone h4
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62805
  Domains in SCOPe 2.08: d5bnve_
• Chain 'F':
  Compound: DNA replication licensing factor mcm2
  Species: Homo sapiens [TaxId:9606]
  Gene: MCM2, BM28, CCNL1, CDCL1, KIAA0030
  Database cross-references and differences (RAF-indexed):
  • Uniprot P49736
• Heterogens: PO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >5bnvA (A:)
  stellirklpfqrlvreiaqdfktdlrfqsaaigalqeaseaylvglfedtnlcaihakr
  vtimpkdiqlarrirgera
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5bnvA (A:)
  tellirklpfqrlvreiaqdfktdlrfqsaaigalqeaseaylvglfedtnlcaihakrv
  timpkdiqlarrirger
  

  
  
• Chain 'B':
  Sequence, based on SEQRES records: (download)
  

  >5bnvB (B:)
  sgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkv
  flenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5bnvB (B:)
  rkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakr
  ktvtamdvvyalkrqgrtl
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence, based on SEQRES records: (download)
  

  >5bnvD (D:)
  stellirklpfqrlvreiaqdfktdlrfqsaaigalqeaseaylvglfedtnlcaihakr
  vtimpkdiqlarrirgera
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5bnvD (D:)
  tellirklpfqrlvreiaqdfktdlrfqsaaigalqeaseaylvglfedtnlcaihakrv
  timpkdiqlarrirgera
  

  
  
• Chain 'E':
  Sequence, based on SEQRES records: (download)
  

  >5bnvE (E:)
  sgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkv
  flenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5bnvE (E:)
  iqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrktvtamd
  vvyalkrqg
  

  
  
• Chain 'F':
  No sequence available.