PDB entry 5ap6

View 5ap6 on RCSB PDB site
Description: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Class: transferase
Keywords: transferase, mps1, mitosis
Deposited on 2015-09-14, released 2015-09-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-09-23, with a file datestamp of 2015-09-18.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P33981 (23-End)
      • expression tag (20-22)
      • engineered mutation (108)
    Domains in SCOPe 2.08: d5ap6a1, d5ap6a2
  • Heterogens: PWU, EDO, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ap6A (A:)
mhhhhhhssgvdlgtenlyfqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyv
nleeadnqtldsyrneiaylnklqqhsdkiirlydyeitdqyiymvmewgnidlnswlkk
kksidpwerksywknmleavhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdt
tsvvkdsqvgtvnymppeaikdmsssrengkskskispksdvwslgcilyymtygktpfq
qiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqt
hpvnqmakgttee

    Sequence, based on observed residues (ATOM records): (download) 
    >5ap6A (A:)
qsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmewgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpddsqvgtvnymppeaikdmkis
pksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkccl
krdpkqrisipellahpyvqiq