PDB entry 5agz

View 5agz on RCSB PDB site
Description: Disubstituted bis-THF moieties as new P2 ligands in non-peptidal HIV- 1 Protease Inhibitors (II)
Class: hydrolase
Keywords: hydrolase, inhibitor, rational drug design, bis-thf bis-diol
Deposited on 2015-02-04, released 2015-05-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-05-27, with a file datestamp of 2015-05-22.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (Z2/CDC-Z34 ISOLATE) [TaxId:11683]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366
    • engineered mutation (62)
    • engineered mutation (81)
    • engineered mutation (83)
  Domains in SCOPe 2.06: d5agza_
• Chain 'B':
  Compound: Protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (Z2/CDC-Z34 ISOLATE) [TaxId:11683]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-98)
    • engineered mutation (62)
    • engineered mutation (81)
    • engineered mutation (83)
  Domains in SCOPe 2.06: d5agzb_
• Heterogens: CL, QHA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5agzA (A:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qipieicghkaigtvlvgptptnvigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5agzB (B:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qipieicghkaigtvlvgptptnvigrnlltqigctlnf