PDB entry 5a3t

View 5a3t on RCSB PDB site
Description: Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid).
Class: oxidoreductase
Keywords: oxidoreductase, lysine-specific demethylase 5b
Deposited on 2015-06-02, released 2015-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-06-29, with a file datestamp of 2016-06-24.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific demethylase 5B
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGL1
      • expression tag (0-1)
    Domains in SCOPe 2.08: d5a3ta1, d5a3ta2, d5a3ta3
  • Heterogens: ZN, EPE, MMK, NI, EDO, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5a3tA (A:)
smflpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhf
tpriqrlneleaqtrvklggggardytlrtfgemadafksdyfnmpvhmvptelvekefw
rlvstieedvtveygadiaskefgsgfpvrdgkiklspeeeeyldsgwnlnnmpvmeqsv
lahitadicgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqle
nvmkklapelfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfn
qgfnfaeavnfctvdwlplgrqcvehyrllhrycvfshdemickmaskadvldvvvastv
qkdmaimiedekalretvrklgvidsermdfellpdderqcvkckttcfmsaiscsckpg
llvclhhvkelcscppykyklryrytlddlypmmnalklraesynewalnvnealeakin
k

    Sequence, based on observed residues (ATOM records): (download) 
    >5a3tA (A:)
smflpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhf
tpriqrlneleaqtrvkrdytlrtfgemadafksdyfnmpvhmvptelvekefwrlvsti
eedvtveygadiaskefgsgfpvrdiklspeeeeyldsgwnlnnmpvmeqsvlahitadi
cgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqlenvmkklap
elfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfnqgfnfaea
vnfctvdwlplgrqcvehyrllhrycvfshdemickmaskadvldvvvastvqkdmaimi
edekalretvrklgvidsermdfellpdderqcvkckttcfmsaiscsckpgllvclhhv
kelcscppykyklryrytlddlypmmnalklrae