PDB entry 5a1i

View 5a1i on RCSB PDB site
Description: The structure of Human MAT2A in complex with SAM, Adenosine, Methionine and PPNP.
Class: transferase
Keywords: transferase, methionine adenosyltransferase, cell growth, liver cancer, methylation
Deposited on 2015-04-30, released 2016-03-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-06, with a file datestamp of 2017-12-01.
Experiment type: XRAY
Resolution: 1.09 Å
R-factor: N/A
AEROSPACI score: 0.74 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5a1ia1, d5a1ia2, d5a1ia3
  • Heterogens: MET, PPK, MG, K, SAM, ADN, PEG, EDO, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5a1iA (A:)
mngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetva
ktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqg
vhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpds
ktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedt
iyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarw
vakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvi
vrdldlkkpiyqrtaayghfgrdsfpwevpkklky

    Sequence, based on observed residues (ATOM records): (download) 
    >5a1iA (A:)
egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagd
qglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrga
vlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfvigg
pqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrv
lvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrt
aayghfgrdsfpwevpkklky