PDB entry 4zzl

View 4zzl on RCSB PDB site
Description: MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression
Class: transcription
Keywords: transcription, mexr, mexab-oprm efflux pump, md simulation
Deposited on 2015-04-10, released 2016-07-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-08-24, with a file datestamp of 2016-08-18.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multidrug resistance operon repressor
    Species: Pseudomonas aeruginosa [TaxId:287]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52003 (23-157)
      • expression tag (9-22)
      • engineered mutation (39)
    Domains in SCOPe 2.08: d4zzla1, d4zzla2
  • Chain 'B':
    Compound: Multidrug resistance operon repressor
    Species: Pseudomonas aeruginosa [TaxId:287]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52003 (23-157)
      • engineered mutation (39)
    Domains in SCOPe 2.08: d4zzlb_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zzlA (A:)
mhhhhhhssgvdlgtenlyfqsmvnpdlmpalmavfqhvwtriqseldcqrldltppdvh
vlklideqrglnlqdlgrqmcrdkalitrkirelegrnlvrrernpsdqrsfqlfltdeg
laihqhaeaimsrvhdelfapltpveqatlvhlldqcl

    Sequence, based on observed residues (ATOM records): (download) 
    >4zzlA (A:)
gvdlgtenlyfqsmvnpdlmpalmavfqhvwtriqseldldltppdvhvlklideqrgln
lqdlgrqmcrdkalitrkirelegrnlvrrernpsdqrsfqlfltdeglaihqhaeaims
rvhdelfapltpveqatlvhlldqcl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zzlB (B:)
mhhhhhhssgvdlgtenlyfqsmvnpdlmpalmavfqhvwtriqseldcqrldltppdvh
vlklideqrglnlqdlgrqmcrdkalitrkirelegrnlvrrernpsdqrsfqlfltdeg
laihqhaeaimsrvhdelfapltpveqatlvhlldqcl

    Sequence, based on observed residues (ATOM records): (download) 
    >4zzlB (B:)
vnpdlmpalmavfqhvwtriqseldcqrldltppdvhvlklideqrglnlqdlgrqmcrd
kalitrkirelegrnlvrrernpsdqrsfqlfltdeglaihqhaeaimsrvhdelfaplt
pveqatlvhlldqcl