PDB entry 4zyw

View 4zyw on RCSB PDB site
Description: Human GAR transformylase in complex with GAR and N-({5-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid (AGF94)
Class: transferase/transferase inhibitor
Keywords: gar transformylase, antifolate, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2015-05-22, released 2016-04-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Trifunctional purine biosynthetic protein adenosine-3
    Species: Homo sapiens [TaxId:9606]
    Gene: GART, PGFT, PRGS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4zywa_
  • Heterogens: GAR, G94, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4zywA (A:)
    marvavlisgtgsnlqalidstrepnssaqidivisnkaavagldkaeragiptrvinhk
    lyknrvefdsaidlvleefsidivclagfmrilsgpfvqkwngkmlnihpsllpsfkgsn
    aheqaletgvtvtgctvhfvaedvdagqiilqeavpvkrgdtvatlservklaehkifpa
    alqlvasgtvqlgengkicwvkeehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4zywA (A:)
    arvavlisgtgsnlqalidstrepnssaqidivisnkaavagldkaeragiptrvinhkl
    yknrvefdsaidlvleefsidivclagfmrilsgpfvqkwngkmlnihpsllpsfkgsna
    heqaletgvtvtgctvhfvaedvdagqiilqeavpvkrgdtvatlservklaehkifpaa
    lqlvasgtvqlgengkicwv