PDB entry 4zy3

View 4zy3 on RCSB PDB site
Description: Crystal Structure of Keap1 in Complex with a small chemical compound, K67
Class: transcription
Keywords: Nrf2, Keap1, Stress sensor, Small molecule binding, Double glycine repeat, Kelch domain, p62, Transcription
Deposited on 2015-05-21, released 2016-05-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kelch-like ECH-associated protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Keap1, Inrf2, Kiaa0132
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4zy3a_
  • Chain 'B':
    Compound: Kelch-like ECH-associated protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Keap1, Inrf2, Kiaa0132
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4zy3b_
  • Heterogens: FMT, K67, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zy3A (A:)
mghhhhhhdydipttenlyfqgapkvgrliytaggyfrqslsyleaynpsngswlrladl
qvprsglagcvvggllyavggrnnspdgntdssaldcynpmtnqwspcasmsvprnrigv
gvidghiyavggshgcihhssveryeperdewhlvapmltrrigvgvavlnrllyavggf
dgtnrlnsaecyypernewrmitpmntirsgagvcvlhnciyaaggydgqdqlnsveryd
vetetwtfvapmrhhrsalgitvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmt
sgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >4zy3A (A:)
grliytaggyfrqslsyleaynpsngswlrladlqvprsglagcvvggllyavggrnnsp
dgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyavggshgcihhssverye
perdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitpmn
tirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmrhhrsalgitvhqg
kiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvavt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zy3B (B:)
mghhhhhhdydipttenlyfqgapkvgrliytaggyfrqslsyleaynpsngswlrladl
qvprsglagcvvggllyavggrnnspdgntdssaldcynpmtnqwspcasmsvprnrigv
gvidghiyavggshgcihhssveryeperdewhlvapmltrrigvgvavlnrllyavggf
dgtnrlnsaecyypernewrmitpmntirsgagvcvlhnciyaaggydgqdqlnsveryd
vetetwtfvapmrhhrsalgitvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmt
sgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >4zy3B (B:)
grliytaggyfrqslsyleaynpsngswlrladlqvprsglagcvvggllyavggrnnsp
dgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyavggshgcihhssverye
perdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitpmn
tirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmrhhrsalgitvhqg
kiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvavt