PDB entry 4zxf

View 4zxf on RCSB PDB site
Description: Crystal Structure of a Soluble Variant of Monoglyceride Lipase from Saccharomyces Cerevisiae in Complex with a Substrate Analog
Class: hydrolase
Keywords: Hydrolase, Monoglyceride Lipase, Monoacylglycerol Lipase, Complex, Substrate Analog
Deposited on 2015-05-20, released 2016-05-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Monoglyceride lipase
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: YJU3, YKL094W, YKL441
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28321
      • engineered mutation (201)
      • engineered mutation (290)
    Domains in SCOPe 2.07: d4zxfa_
  • Chain 'B':
    Compound: Monoglyceride lipase
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: YJU3, YKL094W, YKL441
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28321 (27-End)
      • engineered mutation (201)
      • engineered mutation (290)
    Domains in SCOPe 2.07: d4zxfb_
  • Chain 'C':
    Compound: Monoglyceride lipase
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: YJU3, YKL094W, YKL441
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28321 (27-End)
      • engineered mutation (201)
      • engineered mutation (290)
    Domains in SCOPe 2.07: d4zxfc_
  • Chain 'D':
    Compound: Monoglyceride lipase
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: YJU3, YKL094W, YKL441
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28321
      • engineered mutation (201)
      • engineered mutation (290)
    Domains in SCOPe 2.07: d4zxfd_
  • Heterogens: SO4, 4S7, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zxfA (A:)
msyyhhhhhhdydipttenlyfqgamgmapypykvqttvpelqyenfdgakfgymfwpvq
ngtnevrgrvllihgfgeytkiqfrlmdhlslngyesftfdqrgagvtspgrskgvtdey
hvfndlehfveknlseckakgiplfmwghsmgggiclnyacqgkhkneisgyigsgplii
lhphtmynkptqiiapllakfsprvridtgldlkgitsdkayraflgsdpmsvplygsfr
qihdfmqrgaklyknennyiqknfakdkpviimhgqddtindpkgsekfirdcpsadkel
klypgarhsifsletdkvfntvfndmkqwldkhttteakp

    Sequence, based on observed residues (ATOM records): (download) 
    >4zxfA (A:)
apypykvqttvpelqyenfdgakfgymfwpvqngtnevrgrvllihgfgeytkiqfrlmd
hlslngyesftfdqrgagvtspgrskgvtdeyhvfndlehfveknlseckakgiplfmwg
hsmgggiclnyacqgkhkneisgyigsgpliilhphtmynkptqiiapllakfsprvrid
tgldlkgitsdkayraflgsdpmsvplygsfrqihdfmqrgaklyknennyiqknfakdk
pviimhgqddtindpkgsekfirdcpsadkelklypgarhsifsletdkvfntvfndmkq
wldkhttt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zxfB (B:)
msyyhhhhhhdydipttenlyfqgamgmapypykvqttvpelqyenfdgakfgymfwpvq
ngtnevrgrvllihgfgeytkiqfrlmdhlslngyesftfdqrgagvtspgrskgvtdey
hvfndlehfveknlseckakgiplfmwghsmgggiclnyacqgkhkneisgyigsgplii
lhphtmynkptqiiapllakfsprvridtgldlkgitsdkayraflgsdpmsvplygsfr
qihdfmqrgaklyknennyiqknfakdkpviimhgqddtindpkgsekfirdcpsadkel
klypgarhsifsletdkvfntvfndmkqwldkhttteakp

    Sequence, based on observed residues (ATOM records): (download) 
    >4zxfB (B:)
mapypykvqttvpelqyenfdgakfgymfwpvqngvrgrvllihgfgeytkiqfrlmdhl
slngyesftfdqrgagvtspgrskgvtdeyhvfndlehfveknlseckakgiplfmwghs
mgggiclnyacqgkhkneisgyigsgpliilhphtmynkptqiiapllakfsprvridtg
ldlkgitsdkayraflgsdpmsvplygsfrqihdfmqrgaklyknennyiqknfakdkpv
iimhgqddtindpkgsekfirdcpsadkelklypgarhsifsletdkvfntvfndmkqwl
dkhttte

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4zxfC (C:)
msyyhhhhhhdydipttenlyfqgamgmapypykvqttvpelqyenfdgakfgymfwpvq
ngtnevrgrvllihgfgeytkiqfrlmdhlslngyesftfdqrgagvtspgrskgvtdey
hvfndlehfveknlseckakgiplfmwghsmgggiclnyacqgkhkneisgyigsgplii
lhphtmynkptqiiapllakfsprvridtgldlkgitsdkayraflgsdpmsvplygsfr
qihdfmqrgaklyknennyiqknfakdkpviimhgqddtindpkgsekfirdcpsadkel
klypgarhsifsletdkvfntvfndmkqwldkhttteakp

    Sequence, based on observed residues (ATOM records): (download) 
    >4zxfC (C:)
mapypykvqttvpelqyenfdgakfgymfwpvqngtnevrgrvllihgfgeytkiqfrlm
dhlslngyesftfdqrgagvtspgrskgvtdeyhvfndlehfveknlseckakgiplfmw
ghsmgggiclnyacqgkhkneisgyigsgpliilhphtmynkptqiiapllakfsprvri
dtgldlkgitsdkayraflgsdpmsvplygsfrqihdfmqrgaklyknennyiqknfakd
kpviimhgqddtindpkgsekfirdcpsadkelklypgarhsifsletdkvfntvfndmk
qwldkht

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4zxfD (D:)
msyyhhhhhhdydipttenlyfqgamgmapypykvqttvpelqyenfdgakfgymfwpvq
ngtnevrgrvllihgfgeytkiqfrlmdhlslngyesftfdqrgagvtspgrskgvtdey
hvfndlehfveknlseckakgiplfmwghsmgggiclnyacqgkhkneisgyigsgplii
lhphtmynkptqiiapllakfsprvridtgldlkgitsdkayraflgsdpmsvplygsfr
qihdfmqrgaklyknennyiqknfakdkpviimhgqddtindpkgsekfirdcpsadkel
klypgarhsifsletdkvfntvfndmkqwldkhttteakp

    Sequence, based on observed residues (ATOM records): (download) 
    >4zxfD (D:)
pypykvqttvpelqyenfdgakfgymfwpvqngtrgrvllihgfgeytkiqfrlmdhlsl
ngyesftfdqrgagvtspgrskgvtdeyhvfndlehfveknplfmwghsmgggiclnyac
qgkhkneisgyigsgpliilhphtmynkptqiiapllakfsprvridtgldlkgitsdka
yraflgsdpmsvplygsfrqihdfmqrgaklyknennyiqknfakdkpviimhgqddtin
dpkgsekfirdcpsadkelklypgarhsifsletdkvfntvfndmkqwldkht