PDB entry 4zso

View 4zso on RCSB PDB site
Description: Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
Class: immune system
Keywords: Tumor ligand B7-H6, Antibody, IMMUNE SYSTEM
Deposited on 2015-05-13, released 2016-05-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Antibody Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZSO (0-213)
    Domains in SCOPe 2.08: d4zsoa1, d4zsoa2
  • Chain 'B':
    Compound: antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZSO (Start-218)
    Domains in SCOPe 2.08: d4zsob1, d4zsob2
  • Chain 'C':
    Compound: Antibody Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZSO (0-213)
    Domains in SCOPe 2.08: d4zsoc1, d4zsoc2
  • Chain 'D':
    Compound: antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZSO (0-218)
    Domains in SCOPe 2.08: d4zsod1, d4zsod2
  • Chain 'E':
    Compound: Natural cytotoxicity triggering receptor 3 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCR3LG1, B7H6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q68D85 (6-End)
      • expression tag (4-5)
  • Chain 'F':
    Compound: Natural cytotoxicity triggering receptor 3 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCR3LG1, B7H6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q68D85 (6-End)
      • expression tag (5)
  • Heterogens: SO4, ACY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4zsoA (A:)
mqivltqspalmsaspgekvtmtcsasssvsymywyqqkprsspkpwiyltsnlasgvpa
rfcgsgsgtsysltissmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zsoB (B:)
mqvqlqqpgaelvkpgasvkmsckasgytftsynmhwvkqtpgqglewigaiypgngdts
ynqkfkgkatltadkssstaymqlssltsedsavyycareglgallrdlyywgqgtsvtv
ssakttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlq
sdlytlsssvtvtsstwpsqsitcnvahpasstkvdkki

    Sequence, based on observed residues (ATOM records): (download) 
    >4zsoB (B:)
qvqlqqpgaelvkpgasvkmsckasgytftsynmhwvkqtpgqglewigaiypgngdtsy
nqkfkgkatltadkssstaymqlssltsedsavyycareglgallrdlyywgqgtsvtvs
sakttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqs
dlytlsssvtvtsstwpsqsitcnvahpasstkvdkki

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4zsoC (C:)
mqivltqspalmsaspgekvtmtcsasssvsymywyqqkprsspkpwiyltsnlasgvpa
rfcgsgsgtsysltissmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4zsoD (D:)
mqvqlqqpgaelvkpgasvkmsckasgytftsynmhwvkqtpgqglewigaiypgngdts
ynqkfkgkatltadkssstaymqlssltsedsavyycareglgallrdlyywgqgtsvtv
ssakttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlq
sdlytlsssvtvtsstwpsqsitcnvahpasstkvdkki

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.