PDB entry 4zsa

View 4zsa on RCSB PDB site
Description: Crystal structure of FGFR1 kinase domain in complex with 7n
Class: transferase/transferase inhibitor
Keywords: FGFR1 inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2015-05-13, released 2015-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-07-22, with a file datestamp of 2015-07-17.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (Start-307)
      • engineered mutation (30)
    Domains in SCOPe 2.08: d4zsaa_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (30)
    Domains in SCOPe 2.08: d4zsab_
  • Heterogens: 4UT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zsaA (A:)
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
valtsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4zsaA (A:)
elpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppeeql
sskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardihhidyyk
kttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllke
ghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zsaB (B:)
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
valtsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4zsaB (B:)
eyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdat
ekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppee
qlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglidyykkttn
grlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrm
dkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalt