PDB entry 4zlo

View 4zlo on RCSB PDB site
Description: Serine/threonine-protein kinase PAK1 complexed with a dibenzodiazepine: identification of an allosteric site on PAK1
Class: Transferase/transferase inhibitor
Keywords: dibenzodazepine, PAK1, kinase, allosteric inhibitor, Transferase-transferase inhibitor complex
Deposited on 2015-05-01, released 2015-08-05
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-08-05, with a file datestamp of 2015-07-31.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PAK 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4zloa_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase PAK 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4zlob_
  • Heterogens: 4PV, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zloA (A:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrdiksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatknnh

    Sequence, based on observed residues (ATOM records): (download) 
    >4zloA (A:)
deeileklrsivsvgdpkkkytrfekigqsgtvytamdvatgqevaikqmnkkeliinei
lvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcreclqa
leflhsnqvihrdiksdnillgmdgsvkltdfgskrstmvgtpywmapevvtrkaygpkv
diwslgimaiemiegeppylnenplralyliatngtpelqnpeklsaifrdflnrclemd
vekrgsakellqhqflkiakplssltpliaaakeatkn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zloB (B:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrdiksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatknnh

    Sequence, based on observed residues (ATOM records): (download) 
    >4zloB (B:)
ileklrsivsvkkkytrfekigqvytamgqevaikqmeliineilvmrenknpnivnyld
syvvmeylaggsltdvvtetcmdegqiaavcreclqaleflhsnqvihrdiksdnillgm
dgsvkltdfgfcaqitpeqskrstmvgtpywmapevvtrkaygpkvdiwslgimaiemie
geppylnenplralyliatngtpelqnpeklsaifrdflnrclemdvekrgsakellqhq
flkiakplssltpliaaakeatkn