PDB entry 4zhk

View 4zhk on RCSB PDB site
Description: Crystal structure of RPE65 in complex with MB-002
Class: Hydrolase,Isomerase
Keywords: 7-bladed beta propeller, monotopic membrane protein, non-heme iron protein, retinoid isomerase, smooth endoplasmic reticulum, isomerase, Hydrolase
Deposited on 2015-04-25, released 2015-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-07, with a file datestamp of 2021-07-02.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (0-531)
      • conflict (339)
    Domains in SCOPe 2.08: d4zhka_
  • Chain 'B':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (0-531)
      • conflict (339)
    Domains in SCOPe 2.08: d4zhkb_
  • Heterogens: FE2, PG4, NA, PGE, A8V, A9V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zhkA (A:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrffs
yfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahp
hiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyvh
sfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyin
nkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarkap
qpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpqi
nyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdalee
ddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >4zhkA (A:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpevtdnalvniyp
vgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfia
ynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfk
flsswslwganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedhef
livdlccwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknl
vtlpnttatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfv
pdrlcklnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayll
ilnakdlsevaraeveinipvtfhglfkks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zhkB (B:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrffs
yfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahp
hiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyvh
sfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyin
nkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarkap
qpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpqi
nyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdalee
ddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >4zhkB (B:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpevtdnalvniyp
vgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfia
ynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfk
flsswslwganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedhef
livdlccwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknl
vtlpnttatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfv
pdrlcklnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayll
ilnakdlsevaraeveinipvtfhglfkks