PDB entry 4z78

View 4z78 on RCSB PDB site
Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Class: immune system
Keywords: Immunoglobulin, H-2Kd, Type 1 Diabetes, Immune System
Deposited on 2015-04-06, released 2015-06-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-08-12, with a file datestamp of 2015-08-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.07: d4z78a1, d4z78a2, d4z78a3
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4z78b1, d4z78b2
  • Chain 'C':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.07: d4z78d1, d4z78d2, d4z78d3
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4z78e1, d4z78e2
  • Chain 'F':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.07: d4z78g1, d4z78g2, d4z78g3
  • Chain 'H':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4z78h1, d4z78h2
  • Chain 'I':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EDO, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z78A (A:)
    mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
    weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
    grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
    lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
    tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z78B (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z78D (D:)
    mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
    weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
    grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
    lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
    tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z78E (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z78G (G:)
    mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
    weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
    grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
    lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
    tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z78H (H:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'I':
    No sequence available.