PDB entry 4z76

View 4z76 on RCSB PDB site
Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Class: immune system
Keywords: Immunoglobulin, H-2Kd, Type 1 Diabetes, Immune System
Deposited on 2015-04-06, released 2015-06-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-08-12, with a file datestamp of 2015-08-07.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.07: d4z76a1, d4z76a2, d4z76a3
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4z76b1, d4z76b2
  • Chain 'C':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01308 (0-8)
      • conflict (8)
  • Chain 'D':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.07: d4z76d1, d4z76d2, d4z76d3
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4z76e1, d4z76e2
  • Chain 'F':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01308 (0-8)
      • conflict (8)
  • Heterogens: EDO, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z76A (A:)
    mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
    weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
    grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
    lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
    tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z76B (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z76D (D:)
    mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
    weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
    grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
    lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
    tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4z76E (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.