PDB entry 4z4x

View 4z4x on RCSB PDB site
Description: Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20D25N with Open Flap
Class: hydrolase
Keywords: HIV-1 Protease, HYDROLASE
Deposited on 2015-04-02, released 2015-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protease
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q0PQ60
      • engineered mutation (6)
      • engineered mutation (24)
      • engineered mutation (31)
      • engineered mutation (36)
      • engineered mutation (46)
      • engineered mutation (53)
      • engineered mutation (57)
      • engineered mutation (66)
      • engineered mutation (70)
      • engineered mutation (88)
      • engineered mutation (92)
      • engineered mutation (94)
    Domains in SCOPe 2.08: d4z4xa_
  • Chain 'B':
    Compound: Protease
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q0PQ60 (0-98)
      • engineered mutation (6)
      • engineered mutation (24)
      • engineered mutation (31)
      • engineered mutation (36)
      • engineered mutation (46)
      • engineered mutation (53)
      • engineered mutation (57)
      • engineered mutation (66)
      • engineered mutation (70)
      • engineered mutation (88)
      • engineered mutation (92)
      • engineered mutation (94)
    Domains in SCOPe 2.08: d4z4xb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z4xA (A:)
pqitlwkrpfvtvkvggqlkeallntgadntifedinlpgrwkpkmvggiggflkvreyd
qvpieiaghkvigtvlvgptpvnvigrdtmtqigatlnf

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z4xB (B:)
pqitlwkrpfvtvkvggqlkeallntgadntifedinlpgrwkpkmvggiggflkvreyd
qvpieiaghkvigtvlvgptpvnvigrdtmtqigatlnf