PDB entry 4z22

View 4z22 on RCSB PDB site
Description: structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor DR718A
Class: hydrolase
Keywords: plasmepsin II, malaria, inhibitor, hydrolase
Deposited on 2015-03-28, released 2016-01-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-01-13, with a file datestamp of 2016-01-08.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Plasmepsin-2
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PFAG_05140
    Database cross-references and differences (RAF-indexed):
    • Uniprot W7FL77 (0-328)
      • engineered mutation (204)
    Domains in SCOPe 2.06: d4z22a_
  • Chain 'B':
    Compound: Plasmepsin-2
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PFAG_05140
    Database cross-references and differences (RAF-indexed):
    • Uniprot W7FL77 (0-328)
      • engineered mutation (204)
    Domains in SCOPe 2.06: d4z22b_
  • Heterogens: 4KG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z22A (A:)
ssndnielvdfqnimfygdaevgdnqqpftfildtgsanlwvpsvkcttagcltkhlyds
sksrtyekdgtkvemnyvsgtvsgffskdlvtvgnlslpykfievidtngfeptytastf
dgilglgwkdlsigsvdpivvelknqnkienalftfylpvhdkhtgfltiggieerfyeg
pltyeklnhdlywqitldahvgnislekancivdsgtsaitvptdflnkmlqnldvikvp
flpfyvtlcnnsklptfeftsengkytlepeyylqhiedvgpglcmlniigldfpvptfi
lgdpfmrkyftvfdydnhsvgialakknl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z22B (B:)
ssndnielvdfqnimfygdaevgdnqqpftfildtgsanlwvpsvkcttagcltkhlyds
sksrtyekdgtkvemnyvsgtvsgffskdlvtvgnlslpykfievidtngfeptytastf
dgilglgwkdlsigsvdpivvelknqnkienalftfylpvhdkhtgfltiggieerfyeg
pltyeklnhdlywqitldahvgnislekancivdsgtsaitvptdflnkmlqnldvikvp
flpfyvtlcnnsklptfeftsengkytlepeyylqhiedvgpglcmlniigldfpvptfi
lgdpfmrkyftvfdydnhsvgialakknl