PDB entry 4yz3

View 4yz3 on RCSB PDB site
Description: Crystal Structure of Streptococcus pneumoniae NanC, in complex with Oseltamivir.
Class: hydrolase
Keywords: Sialidase, Neuraminidase, Beta-propeller, CBM40, hydrolase
Deposited on 2015-03-24, released 2016-04-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-13, with a file datestamp of 2017-09-08.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: Streptococcus pneumoniae serotype 4 [TaxId:170187]
    Gene: SP_1326
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4yz3a1, d4yz3a2
  • Chain 'B':
    Compound: Neuraminidase
    Species: Streptococcus pneumoniae serotype 4 [TaxId:170187]
    Gene: SP_1326
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q97Q99 (20-676)
      • expression tag (19)
    Domains in SCOPe 2.07: d4yz3b1, d4yz3b2, d4yz3b3
  • Heterogens: G39, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4yz3A (A:)
mahhhhhhssglevlfqgpntpvleknnvtltgggenvtkelkdkftsgdftvvikynqs
sekglqalfgisnskpgqqnsyvdvflrdngelgmeardtssnknnlvsrpasvwgkykq
eavtntvavvadsvkktyslyangtkvvekkvdnflnikdikgidyymlggvkragktaf
gfngtlenikffnsaldeetvkkmttnavtghliytandttgsnyfripvlytfsngrvf
ssidaryggthdflnkiniatsysddngktwtkpkltlafddfapvplewprevggrdlq
isggatyidsvivekknkqvlmfadvmpagvsfreatrkdsgykqidgnyylklrkqgdt
dynytirengtvyddrtnrptefsvdknfgikqngnyltveqysvsfennkkteyrngtk
vhmnifykdalfkvvptnyiayissndhgeswsaptllppimglnrnapylgpgrgiies
stgrilipsytgkesafiysddngaswkvkvvplpsswsaeaqfvelspgviqaymrtnn
gkiayltskdagttwsapeylkfvsnpsygtqlsiinysqlidgkkavilstpnstngrk
hgqiwiglinddntidwryhhdvdysnygysystltelpnheiglmfekfdswsrnelhm
knvvpyitfkiedlkkn

    Sequence, based on observed residues (ATOM records): (download) 
    >4yz3A (A:)
tpvleknnvtltgggenvtkelkdkftsgdftvvikynqssekglqalfgisnskpgqqn
syvdvflrdngelgmeardtssnknnlvsrpasvwgkykqeavtntvavvadsvkktysl
yangtkvvekkvdnflnikdikgidyymlggvkragktafgfngtlenikffnsaldeet
vkkmttnavtghliytandttgsnyfripvlytfsngrvfssidaryggthdflnkinia
tsysddngktwtkpkltlafddfapvplewprevggrdlqisggatyidsvivekknkqv
lmfadvmpagvsfreatrkdsgykqidgnyylklrkqgdtdynytirengtvyddrtnrp
tefsvdknfgikqngnyltveqysvsfkkteyrngtkvhmnifykdalfkvvptnyiayi
ssndhgeswsaptllppimglnrnapylgpgrgiiesstgrilipsytgkesafiysddn
gaswkvkvvplpsswsaeaqfvelspgviqaymrtnngkiayltskdagttwsapeylkf
vsnpsygtqlsiinysqlidgkkavilstpnstngrkhgqiwiglinddntidwryhhdv
dysnygysystltelpnheiglmfekfdswsrnelhmknvvpyitfkiedlkkn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4yz3B (B:)
mahhhhhhssglevlfqgpntpvleknnvtltgggenvtkelkdkftsgdftvvikynqs
sekglqalfgisnskpgqqnsyvdvflrdngelgmeardtssnknnlvsrpasvwgkykq
eavtntvavvadsvkktyslyangtkvvekkvdnflnikdikgidyymlggvkragktaf
gfngtlenikffnsaldeetvkkmttnavtghliytandttgsnyfripvlytfsngrvf
ssidaryggthdflnkiniatsysddngktwtkpkltlafddfapvplewprevggrdlq
isggatyidsvivekknkqvlmfadvmpagvsfreatrkdsgykqidgnyylklrkqgdt
dynytirengtvyddrtnrptefsvdknfgikqngnyltveqysvsfennkkteyrngtk
vhmnifykdalfkvvptnyiayissndhgeswsaptllppimglnrnapylgpgrgiies
stgrilipsytgkesafiysddngaswkvkvvplpsswsaeaqfvelspgviqaymrtnn
gkiayltskdagttwsapeylkfvsnpsygtqlsiinysqlidgkkavilstpnstngrk
hgqiwiglinddntidwryhhdvdysnygysystltelpnheiglmfekfdswsrnelhm
knvvpyitfkiedlkkn

    Sequence, based on observed residues (ATOM records): (download) 
    >4yz3B (B:)
ntpvleknnvtltgggenvtkelkdkftsgdftvvikynqssekglqalfgisnskpgqq
nsyvdvflrdngelgmeardtssnknnlvsrpasvwgkykqeavtntvavvadsvkktys
lyangtkvvekkvdnflnikdikgidyymlggvkragktafgfngtlenikffnsaldee
tvkkmttnavtghliytandttgsnyfripvlytfsngrvfssidaryggthdflnkini
atsysddngktwtkpkltlafddfapvplewprevggrdlqisggatyidsvivekknkq
vlmfadvmpagvsfreatrkdsgykqidgnyylklrkqgdtdynytirengtvyddrtnr
ptefsvdknfgikqngnyltveqysvsfekkteyrngtkvhmnifykdalfkvvptnyia
yissndhgeswsaptllppimglnrnapylgpgrgiiesstgrilipsytgkesafiysd
dngaswkvkvvplpsswsaeaqfvelspgviqaymrtnngkiayltskdagttwsapeyl
kfvsnpsygtqlsiinysqlidgkkavilstpnstngrkhgqiwiglinddntidwryhh
dvdysnygysystltelpnheiglmfekfdswsrnelhmknvvpyitfkiedlkkn