PDB entry 4yu9

View 4yu9 on RCSB PDB site
Description: Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase
Class: transferase
Keywords: Alzheimer Disease, Drug Target, Transferase
Deposited on 2015-03-18, released 2015-08-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-08-19, with a file datestamp of 2015-08-14.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (Start-328)
      • engineered mutation (82)
      • engineered mutation (84)
    Domains in SCOPe 2.08: d4yu9a_
  • Chain 'B':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (Start-328)
      • engineered mutation (82)
      • engineered mutation (84)
    Domains in SCOPe 2.08: d4yu9b_
  • Chain 'C':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (Start-328)
      • engineered mutation (82)
      • engineered mutation (84)
    Domains in SCOPe 2.08: d4yu9c_
  • Heterogens: ZN, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4yu9A (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >4yu9A (A:)
sawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimq
riqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnrvf
vgatdsavpcammlelaraldkkllslktvsskpdlslqliffdgeeaflhwspqdslyg
srhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaie
helhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddn
eenldestidnlnkilqvfvleylhl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4yu9B (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >4yu9B (B:)
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnrvfv
gatdsavpcammlelaraldkkllslktvskpdlslqliffdgeeaflhwspqdslygsr
hlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehe
lhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddnee
nldestidnlnkilqvfvleylhl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4yu9C (C:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >4yu9C (C:)
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnrvfv
gatdsavpcammlelaraldkkllslktvsdspdlslqliffdgeeaflhwspqdslygs
rhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaieh
elhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddne
enldestidnlnkilqvfvleylhl