PDB entry 4yhf

View 4yhf on RCSB PDB site
Description: Bruton's tyrosine kinase in complex with a t-butyl cyanoacrylamide inhibitor
Class: transferase
Keywords: Covalent inhibitor, cyanoacrylamide, cysteine, transferase
Deposited on 2015-02-27, released 2015-05-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-05-13, with a file datestamp of 2015-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4yhfa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4yhfb_
  • Heterogens: 4C9, NA, EDO, SO4, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4yhfA (A:)
knapstaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsede
fieeakvmmnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllem
ckdvceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpv
rwsppevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphl
asekvytimyscwhekaderptfkillsnildvmdees

    Sequence, based on observed residues (ATOM records): (download) 
    >4yhfA (A:)
gygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmm
nlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceame
yleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlm
yskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytim
yscwhekaderptfkillsnildvmdee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4yhfB (B:)
knapstaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsede
fieeakvmmnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllem
ckdvceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpv
rwsppevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphl
asekvytimyscwhekaderptfkillsnildvmdees

    Sequence, based on observed residues (ATOM records): (download) 
    >4yhfB (B:)
lgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvm
mnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceam
eyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevl
myskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvyti
myscwhekaderptfkillsnildvmdee