PDB entry 4y9g
View 4y9g on RCSB PDB site
Description: Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin
Class: transport protein/inhibitor
Keywords: transthyretin, inhibitor, natural product, mangostin, transporter, amyloidosis, kinetic stabilizer, TRANSPORT PROTEIN-INHIBITOR complex
Deposited on
2015-02-17, released
2015-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-02-05, with a file datestamp of
2020-01-31.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: N/A
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4y9ga_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: TTR, PALB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4y9gb_ - Heterogens: MKU, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4y9gA (A:)
mrgshhhhhhgsmashrllllclaglvfvseagptgtgeskcplmvkvldavrgspainv
amhvfrkaaddtwepfasgktsesgelhgltteeefvegiykveidtksywkalgispfh
ehaevvftandsgprrytiaallspysysttavvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4y9gA (A:)
cplmvkvldavrgspainvamhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4y9gB (B:)
mrgshhhhhhgsmashrllllclaglvfvseagptgtgeskcplmvkvldavrgspainv
amhvfrkaaddtwepfasgktsesgelhgltteeefvegiykveidtksywkalgispfh
ehaevvftandsgprrytiaallspysysttavvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4y9gB (B:)
cplmvkvldavrgspainvamhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn