PDB entry 4y9b

View 4y9b on RCSB PDB site
Description: Crystal structure of V30M mutated transthyretin in complex with alpha-mangostin
Class: transport protein/inhibitor
Keywords: transporter, natural product, inhibitor, amyloidosis, TRANSPORT PROTEIN-INHIBITOR complex
Deposited on 2015-02-17, released 2015-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (61)
    Domains in SCOPe 2.08: d4y9ba_
  • Chain 'B':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (61)
    Domains in SCOPe 2.08: d4y9bb_
  • Heterogens: MKS, CL, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4y9bA (A:)
mrgshhhhhhgsmashrllllclaglvfvseagptgtgeskcplmvkvldavrgspainv
amhvfrkaaddtwepfasgktsesgelhgltteeefvegiykveidtksywkalgispfh
ehaevvftandsgprrytiaallspysysttavvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >4y9bA (A:)
cplmvkvldavrgspainvamhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4y9bB (B:)
mrgshhhhhhgsmashrllllclaglvfvseagptgtgeskcplmvkvldavrgspainv
amhvfrkaaddtwepfasgktsesgelhgltteeefvegiykveidtksywkalgispfh
ehaevvftandsgprrytiaallspysysttavvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >4y9bB (B:)
cplmvkvldavrgspainvamhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn