PDB entry 4y95
View 4y95 on RCSB PDB site
Description: Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop
Class: transferase
Keywords: Btk, kinase domain, TRANSFERASE
Deposited on
2015-02-16, released
2015-03-18
The last revision prior to the SCOPe 2.05 freeze date was dated
2015-03-18, with a file datestamp of
2015-03-13.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Non-specific protein-tyrosine kinase
Species: Bos taurus [TaxId:9913]
Gene: BTK
Database cross-references and differences (RAF-indexed):
- Uniprot Q3ZC95 (1-265)
- expression tag (0)
- engineered mutation (148-149)
- engineered mutation (151)
- engineered mutation (161)
- engineered mutation (163)
- engineered mutation (168)
- engineered mutation (170-171)
- engineered mutation (223)
Domains in SCOPe 2.05: d4y95a_ - Chain 'B':
Compound: Non-specific protein-tyrosine kinase
Species: Bos taurus [TaxId:9913]
Gene: BTK
Database cross-references and differences (RAF-indexed):
- Uniprot Q3ZC95 (1-265)
- expression tag (0)
- engineered mutation (148-149)
- engineered mutation (151)
- engineered mutation (161)
- engineered mutation (163)
- engineered mutation (168)
- engineered mutation (170-171)
- engineered mutation (223)
Domains in SCOPe 2.05: d4y95b_ - Chain 'C':
Compound: Non-specific protein-tyrosine kinase
Species: Bos taurus [TaxId:9913]
Gene: BTK
Database cross-references and differences (RAF-indexed):
- Uniprot Q3ZC95 (1-265)
- expression tag (0)
- engineered mutation (148-149)
- engineered mutation (151)
- engineered mutation (161)
- engineered mutation (163)
- engineered mutation (168)
- engineered mutation (170-171)
- engineered mutation (223)
Domains in SCOPe 2.05: d4y95c_ - Chain 'D':
Compound: Non-specific protein-tyrosine kinase
Species: Bos taurus [TaxId:9913]
Gene: BTK
Database cross-references and differences (RAF-indexed):
- Uniprot Q3ZC95 (1-265)
- engineered mutation (148-149)
- engineered mutation (151)
- engineered mutation (161)
- engineered mutation (163)
- engineered mutation (168)
- engineered mutation (170-171)
- engineered mutation (223)
Domains in SCOPe 2.05: d4y95d_ - Heterogens: 746, GOL, BME, PE4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4y95A (A:)
aweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdfgmtrfvlddeytsstgtkfpvkwaspevlmysk
fssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlprphlaservyaimysc
whekaderptfkillsnildvmdees
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4y95B (B:)
aweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdfgmtrfvlddeytsstgtkfpvkwaspevlmysk
fssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlprphlaservyaimysc
whekaderptfkillsnildvmdees
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>4y95C (C:)
aweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdfgmtrfvlddeytsstgtkfpvkwaspevlmysk
fssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlprphlaservyaimysc
whekaderptfkillsnildvmdees
- Chain 'D':
Sequence, based on SEQRES records: (download)
>4y95D (D:)
aweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdfgmtrfvlddeytsstgtkfpvkwaspevlmysk
fssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlprphlaservyaimysc
whekaderptfkillsnildvmdees
Sequence, based on observed residues (ATOM records): (download)
>4y95D (D:)
weidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlsh
eklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyles
kqflhrdlaarnclvndqgvvkvsdfgmtrfvlddeytsstgtkfpvkwaspevlmyskf
ssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlprphlaservyaimyscw
hekaderptfkillsnildvmdees