PDB entry 4y2h

View 4y2h on RCSB PDB site
Description: Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl pyrazole inhibitor
Class: transferase
Keywords: transferase
Deposited on 2015-02-09, released 2015-04-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4y2ha_
  • Chain 'B':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96LA8 (3-351)
      • expression tag (0-2)
    Domains in SCOPe 2.07: d4y2hb1, d4y2hb2
  • Heterogens: SAH, 49K, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4y2hA (A:)
siaaereaalerprrtkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrg
ktvldvgagtgilsifcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetv
elpeqvdaivsewmgygllhesmlssvlhartkwlkegglllpasaelfiapisdqmlew
rlgfwsqvkqhygvdmsclegfatrclmghseivvqglsgedvlarpqrfaqlelsragl
eqeleagvggrfrcscygsapmhgfaiwfqvtfpggesekplvlstspfhpathwkqall
ylnepvqveqdtdvsgeitllpsrdnprrlrvllrykvgdqeektkdfamed

    Sequence, based on observed residues (ATOM records): (download) 
    >4y2hA (A:)
tkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrgktvldvgagtgilsi
fcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetvelpeqvdaivsewmg
ygllhesmlssvlhartkwlkegglllpasaelfiapisdqmlewrlgfwsqvkqhygvd
msclegfatrclmghseivvqglsgedvlarpqrfaqlelsragleqeleagvggrfrcs
cygsapmhgfaiwfqvtfpggesekplvlstspfhpathwkqallylnepvqveqdtdvs
geitllpsrdnprrlrvllrykvgdqeektkdfamed

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4y2hB (B:)
siaaereaalerprrtkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrg
ktvldvgagtgilsifcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetv
elpeqvdaivsewmgygllhesmlssvlhartkwlkegglllpasaelfiapisdqmlew
rlgfwsqvkqhygvdmsclegfatrclmghseivvqglsgedvlarpqrfaqlelsragl
eqeleagvggrfrcscygsapmhgfaiwfqvtfpggesekplvlstspfhpathwkqall
ylnepvqveqdtdvsgeitllpsrdnprrlrvllrykvgdqeektkdfamed