PDB entry 4xzu
View 4xzu on RCSB PDB site
Description: Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody
Class: immune system
Keywords: immunoglobulin, blood coagulation, antibody, discoidin, IMMUNE SYSTEM
Deposited on
2015-02-05, released
2015-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-04, with a file datestamp of
2019-11-29.
Experiment type: XRAY
Resolution: 2.61 Å
R-factor: N/A
AEROSPACI score: 0.18
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 3E6 antibody Fab heavy chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4xzua_ - Chain 'B':
Compound: 3E6 antibody Fab light chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4xzub1, d4xzub2 - Chain 'E':
Compound: 3E6 antibody Fab heavy chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4xzue_ - Chain 'F':
Compound: 3E6 antibody Fab light chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4xzuf1, d4xzuf2 - Chain 'G':
Compound: coagulation factor viii
Species: Homo sapiens [TaxId:9606]
Gene: F8, F8C
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4xzug_ - Chain 'M':
Compound: coagulation factor viii
Species: Homo sapiens [TaxId:9606]
Gene: F8, F8C
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4xzum_ - Heterogens: MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4xzuA (A:)
qiqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpay
addfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktt
apsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprgpa
Sequence, based on observed residues (ATOM records): (download)
>4xzuA (A:)
iqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpaya
ddfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktta
psvyplapvcttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlsss
vtvtsstwpsqsitcnvahpasstkvdkkiepr
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4xzuB (B:)
qivltqspaimsaspgekvtmtcsasstvsymywyqqkpgssprflisdtsnlasgvpvr
fsgsgsgtsysltisrieaedaatyycqhwssypltfgggtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathststspivksfnrnec
- Chain 'E':
Sequence, based on SEQRES records: (download)
>4xzuE (E:)
qiqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpay
addfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktt
apsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprgpa
Sequence, based on observed residues (ATOM records): (download)
>4xzuE (E:)
iqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpaya
ddfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktta
psvyplapgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlsssvtvt
sstwpsqsitcnvahpasstkvdkkiep
- Chain 'F':
Sequence, based on SEQRES records: (download)
>4xzuF (F:)
qivltqspaimsaspgekvtmtcsasstvsymywyqqkpgssprflisdtsnlasgvpvr
fsgsgsgtsysltisrieaedaatyycqhwssypltfgggtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathststspivksfnrnec
Sequence, based on observed residues (ATOM records): (download)
>4xzuF (F:)
qivltqspaimsaspgekvtmtcsasstvsymywyqqkpgssprflisdtsnlasgvpvr
fsgsgsgtsysltisrieaedaatyycqhwssypltfgggtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkqngvlnswtdqdskdstysmsstltltkdeye
tceathivksfnrne
- Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)
>4xzuG (G:)
csmplgmeskaisdaqitassyftnmfatwspskarlhlqgrsnawrpqvnnpkewlqvd
fqktmkvtgvttqgvkslltsmyvkeflisssqdghqwtlffqngkvkvfqgnqdsftpv
vnsldpplltrylrihpqswvhqialrmevlgce
- Chain 'M':
Sequence; same for both SEQRES and ATOM records: (download)
>4xzuM (M:)
csmplgmeskaisdaqitassyftnmfatwspskarlhlqgrsnawrpqvnnpkewlqvd
fqktmkvtgvttqgvkslltsmyvkeflisssqdghqwtlffqngkvkvfqgnqdsftpv
vnsldpplltrylrihpqswvhqialrmevlgce