PDB entry 4xzu

View 4xzu on RCSB PDB site
Description: Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody
Class: immune system
Keywords: immunoglobulin, blood coagulation, antibody, discoidin, IMMUNE SYSTEM
Deposited on 2015-02-05, released 2015-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.61 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3E6 antibody Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4XZU
    Domains in SCOPe 2.08: d4xzua_
  • Chain 'B':
    Compound: 3E6 antibody Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4XZU (0-212)
    Domains in SCOPe 2.08: d4xzub1, d4xzub2
  • Chain 'E':
    Compound: 3E6 antibody Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4XZU
    Domains in SCOPe 2.08: d4xzue_
  • Chain 'F':
    Compound: 3E6 antibody Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4XZU (0-End)
    Domains in SCOPe 2.08: d4xzuf1, d4xzuf2
  • Chain 'G':
    Compound: coagulation factor viii
    Species: Homo sapiens [TaxId:9606]
    Gene: F8, F8C
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xzug_
  • Chain 'M':
    Compound: coagulation factor viii
    Species: Homo sapiens [TaxId:9606]
    Gene: F8, F8C
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xzum_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xzuA (A:)
qiqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpay
addfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktt
apsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprgpa

    Sequence, based on observed residues (ATOM records): (download) 
    >4xzuA (A:)
iqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpaya
ddfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktta
psvyplapvcttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlsss
vtvtsstwpsqsitcnvahpasstkvdkkiepr

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4xzuB (B:)
qivltqspaimsaspgekvtmtcsasstvsymywyqqkpgssprflisdtsnlasgvpvr
fsgsgsgtsysltisrieaedaatyycqhwssypltfgggtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathststspivksfnrnec

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4xzuE (E:)
qiqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpay
addfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktt
apsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkieprgpa

    Sequence, based on observed residues (ATOM records): (download) 
    >4xzuE (E:)
iqlvqsgpelkkpgktvkisckasdytftdyslhwvkqapgkglkwmgwintetgdpaya
ddfkgrfafsletsvrtaylqinnlknedtaiyfcareddglaswgqgttltvssaktta
psvyplapgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlsssvtvt
sstwpsqsitcnvahpasstkvdkkiep

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4xzuF (F:)
qivltqspaimsaspgekvtmtcsasstvsymywyqqkpgssprflisdtsnlasgvpvr
fsgsgsgtsysltisrieaedaatyycqhwssypltfgggtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathststspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >4xzuF (F:)
qivltqspaimsaspgekvtmtcsasstvsymywyqqkpgssprflisdtsnlasgvpvr
fsgsgsgtsysltisrieaedaatyycqhwssypltfgggtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkqngvlnswtdqdskdstysmsstltltkdeye
tceathivksfnrne

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4xzuG (G:)
csmplgmeskaisdaqitassyftnmfatwspskarlhlqgrsnawrpqvnnpkewlqvd
fqktmkvtgvttqgvkslltsmyvkeflisssqdghqwtlffqngkvkvfqgnqdsftpv
vnsldpplltrylrihpqswvhqialrmevlgce

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4xzuM (M:)
csmplgmeskaisdaqitassyftnmfatwspskarlhlqgrsnawrpqvnnpkewlqvd
fqktmkvtgvttqgvkslltsmyvkeflisssqdghqwtlffqngkvkvfqgnqdsftpv
vnsldpplltrylrihpqswvhqialrmevlgce