PDB entry 4xp6

View 4xp6 on RCSB PDB site
Description: X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine
Class: tranport protein/inhibitor
Keywords: integral membrane protein, all-alpha helical antidepressant complex, tranport protein-inhibitor complex
Deposited on 2015-01-16, released 2015-05-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transporter
    Species: Drosophila melanogaster [TaxId:7227]
    Gene: DAT, Dmel_CG8380
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0B4KEX2 (0-533)
      • engineered mutation (49)
      • engineered mutation (349)
  • Chain 'H':
    Compound: antibody fragment light chain-protein, 9d5-light chain
    Species: Mus musculus [TaxId:10090]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4XP6 (0-218)
  • Chain 'L':
    Compound: antibody fragment heavy chain-protein, 9d5-heavy chain
    Species: Mus musculus [TaxId:10090]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4XP6 (0-212)
    Domains in SCOPe 2.07: d4xp6l1, d4xp6l2
  • Heterogens: B40, MAL, NA, CL, NAG, CLR, Y01, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4xp6L (L:)
    envltqspaimstspgekvtmtcrasssvgssylhwyqqksgaspklwiystsnlasgvp
    arfsgsgsgtsysltissveaedaatyycqqfsgypltfgsgtklemkradaaptvsifp
    psseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstl
    tltkdeyerhnsytceathktstspivksfnrn